CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011271
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Eisosome protein 1 
Protein Synonyms/Alias
  
Gene Name
 EIS1 
Gene Synonyms/Alias
 YMR031C; YM9973.04C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
230KERWEPEKTNFQYGVubiquitination[1]
266MAKVDAPKAQDLQKVubiquitination[1]
582AIVDHKRKISGYGNDubiquitination[1]
594GNDLDAQKNRNIREDubiquitination[1]
630IILANKAKEQAELSTubiquitination[1]
643STKEARLKQLEVDSLubiquitination[1]
677LNLLEAMKDVASARGubiquitination[1]
709EEYLTQNKSVEKNVEubiquitination[1]
713TQNKSVEKNVEDLPTubiquitination[1]
756VPVSTAAKEATETSSubiquitination[1]
768TSSAVQTKEPEEKISubiquitination[1]
803KEISVSQKAGNNKSLubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Required for normal formation of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on plasma membrane and mark the site of endocytosis. 
Sequence Annotation
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine.
 MOD_RES 88 88 Phosphoserine.
 MOD_RES 130 130 Phosphoserine.
 MOD_RES 182 182 Phosphoserine.
 MOD_RES 401 401 Phosphoserine.
 MOD_RES 584 584 Phosphoserine.
 MOD_RES 710 710 Phosphoserine.
 MOD_RES 720 720 Phosphothreonine.
 MOD_RES 763 763 Phosphoserine.
 MOD_RES 775 775 Phosphoserine.
 MOD_RES 816 816 Phosphoserine.
 MOD_RES 828 828 Phosphoserine.
 MOD_RES 829 829 Phosphoserine.
 MOD_RES 838 838 Phosphoserine.  
Keyword
 Acetylation; Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 843 AA 
Protein Sequence
MSLISAVEDR DIHNIGKTSG GGSRTSSITS SKKSLKHGSK SLRKPKVYQT TGEPLSREAL 60
YKAKLKYGVY QSPAQSYSIG VSDAHAASDK AANLAHDNQT TVEAYKRMFI DPNATKAASK 120
MGPKVVRNNS ITSATSKTSK ESQTKRKSKE SPGAAASKAY SMTMETTSLS SQTNSRSYSI 180
TSASSVLSGA SGSFNSTVNP KPKTLNLEKV LVGAEKKAES RIKERWEPEK TNFQYGVKTD 240
EHGNLNQFSF SNEMMNNIMA KVDAPKAQDL QKVKKVSAEK EAKSMKFALG AANAVKDMHP 300
GEDIDKSIAL KAQKRETYLS QLTSQQVLTL ARANVDRQLD IIEKSDMHRK LFTNMEYNKA 360
AVAVAQSNHQ KKTEFHNKIN MGGGLFLSPE DITKIASGLI SPVLGEVSER AEAQRAMDEE 420
IAERTEAYNK SSNEWETMER SIISNDAKVL TTTANRHQTE KKTSQEKIKA SFDALVARMD 480
TKVAERETLL EDTKSKEIEF KKQMQQELKD EKARLDQDLE EWGKKCEQDI TEARKEQEEL 540
LKPYHDDLAN AEAEHKTLVE ERDEINAEIS RLQDAIVDHK RKISGYGNDL DAQKNRNIRE 600
DDKLLELGQT KESLESHLND DVIILANKAK EQAELSTKEA RLKQLEVDSL INERKSELNA 660
TEIELKKEKL NLLEAMKDVA SARGDDKIDE EKVKKLIGMT SEEYLTQNKS VEKNVEDLPT 720
QLEKIEEGDE LKKEEIVGAE TKNSGGDGVP VSTAAKEATE TSSAVQTKEP EEKISIGNKS 780
SGKEDANDCK SAEHSKEISV SQKAGNNKSL GVSPDSLEHT FSGFSQGSSI EDDQDAISNQ 840
EKK 843 
Gene Ontology
 GO:0032126; C:eisosome; IDA:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0070941; P:eisosome assembly; IMP:SGD. 
Interpro
 IPR024527; Eisosome1. 
Pfam
 PF12757; DUF3812 
SMART
  
PROSITE
  
PRINTS