UniProt Accession

 E7EMD0_HUMAN; E7EMD0 

Genbank Protein ID

 AC005067; AC006330 

Genbank Nucleotide ID

  

Protein Name

 NADPH--cytochrome P450 reductase 

Protein Synonyms/Alias

  

Gene Name

 POR 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	QKPPFDAKNPFLAAV	ubiquitination	[1]
228	TKAGRINKGVATNWL	ubiquitination	[2, 3]
351	VYVQHLLKQDREHLW	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 418 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004128; F:cytochrome-b5 reductase activity, acting on NAD(P)H; IEA:Compara.
 GO:0009055; F:electron carrier activity; IEA:Compara.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:Compara.
 GO:0010181; F:FMN binding; IEA:Compara.
 GO:0016787; F:hydrolase activity; IEA:Compara.
 GO:0047726; F:iron-cytochrome-c reductase activity; IEA:Compara.
 GO:0050661; F:NADP binding; IEA:Compara.
 GO:0003958; F:NADPH-hemoprotein reductase activity; IEA:Compara.
 GO:0009437; P:carnitine metabolic process; IEA:Compara.
 GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Compara.
 GO:0071375; P:cellular response to peptide hormone stimulus; IEA:Compara.
 GO:0070988; P:demethylation; IEA:Compara.
 GO:0019395; P:fatty acid oxidation; IEA:Compara.
 GO:0009812; P:flavonoid metabolic process; IEA:Compara.
 GO:0018393; P:internal peptidyl-lysine acetylation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0060192; P:negative regulation of lipase activity; IEA:Compara.
 GO:0043602; P:nitrate catabolic process; IEA:Compara.
 GO:0046210; P:nitric oxide catabolic process; IEA:Compara.
 GO:0045542; P:positive regulation of cholesterol biosynthetic process; IEA:Compara.
 GO:0032332; P:positive regulation of chondrocyte differentiation; IEA:Compara.
 GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Compara.
 GO:0090031; P:positive regulation of steroid hormone biosynthetic process; IEA:Compara.
 GO:0003420; P:regulation of growth plate cartilage chondrocyte proliferation; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara. 

Interpro

 IPR003097; FAD-binding_1.
 IPR017927; Fd_Rdtase_FAD-bd.
 IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
 IPR023173; NADPH_Cyt_P450_Rdtase_dom3.
 IPR001433; OxRdtase_FAD/NAD-bd.
 IPR017938; Riboflavin_synthase-like_b-brl. 

Pfam

 PF00667; FAD_binding_1
 PF00175; NAD_binding_1 

SMART

  

PROSITE

 PS51384; FAD_FR 

PRINTS

 PR00371; FPNCR.