| Tag | Content |
|---|
| CPLM ID | CPLM-001444 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 |
Protein Synonyms/Alias | Phosphoinositide phospholipase C-beta-2; Phospholipase C-beta-2; PLC-beta-2 |
Gene Name | Plcb2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1130 | AEYEAKMKGLEAEVK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli. |
Sequence Annotation | DOMAIN 312 463 PI-PLC X-box.
DOMAIN 550 666 PI-PLC Y-box.
DOMAIN 673 771 C2.
ACT_SITE 327 327 By similarity.
ACT_SITE 374 374 By similarity.
METAL 328 328 Calcium (By similarity).
METAL 357 357 Calcium (By similarity).
METAL 359 359 Calcium (By similarity).
METAL 408 408 Calcium (By similarity). |
Keyword | Alternative splicing; Calcium; Coiled coil; Complete proteome; Hydrolase; Lipid degradation; Lipid metabolism; Metal-binding; Reference proteome; Transducer. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1183 AA |
Protein Sequence | MSLLNPVLLP PKVKAYLSQG ERFIKWDDET SIASPVILRV DPKGYYLYWT HQSKEMEFLD 60
VTSIRDTRFG KFAKIPKSQK LREVFNMDFP DNHFLLKTFT VVSGPDMVGL TFHNFVSYKE 120
NVGKDWAEDV LALAKHPMTA NASRSTFLDK ILVKLKMQLS PEGKIPVKNF FQMFPADRKR 180
VEAALSACHL AKGKNDAINP EDFPESVYKS FLMSLCPRPE IDEIFTSYHA KAKPYMTKEH 240
LTKFINQKQR DPRLNSLLFP PARPEQVQAL IDKYEPSGIN VQRGQLSPEG MVWFLCGPEN 300
SVLAHDTLRI HQDMTQPLNH YFINSSHNTY LTAGQFSGPS SAEMYRQVLL SGCRCVELDC 360
WKGKPPDEEP IITHGFTMTT DILFKEAVEA IAESAFKTSP YPVILSFENH VDSPRQQAKM 420
AEYCRTMFGE TLLTEPLENF PLKPGMPLPS PEDLRGKILI KNKKNQFSGP ASPNKKPDGV 480
SEGGFPSSVP VEEDTGWTAE DRTEVEEGEE EEEVEEEEEE ESGNLDEEEI KKMQSDEGTA 540
GLEVTAYEEM SSLVNYIQPT KFISFEFSAQ KNRSYLVSSF TELKAYELLS KASMQFVDYN 600
KRQMSRVYPK GTRMDSSNYM PQMFWNAGCQ MVALNFQTMD LPMQQNMALF EFNGQSGYLL 660
KHEFMRRQDK QFNPFSVDRI DVVVATTLSI TVISGQFLSE RSVRTYVEVE LFGLPGDPKR 720
RYRTKLSPTA NSINPVWKEE PFIFEKILVP ELASLRIAVM EEGGKFIGHR IIPINALHSG 780
YHHLCLRSES NMPLTMPALF VFLEMKDYVP DTWADLTVAL ANPIKYFSAH DKKSVKLKEV 840
TGSLPEKLFS GIPVASQSNG APVSAGNGST APGTKAKEEA TKEVAEPQTT SLEELRELKG 900
VVKLQRRHEK ELRELERRGA RRWEELLQRG AAQLAELQDP AASCKLRPGK GSRKKRIVPC 960
EETIVVPREV LEGPDPRVQD LKDRLEQELQ QQGEEQYRSV LKRKEQHVTE QIAKMMELAR 1020
EKQAAELKSF KETSETDTKE MKKKLEAKRL ERIQAMTKVT TDKVAQERLK REINNSHIQE 1080
VVQAVKQMTE TLERHQEKLE EKQTACLEQI QAMEKQFQEK ALAEYEAKMK GLEAEVKESM 1140
RACFKACFPT EAEEKPERPC EASEESCPQE PLVNKTDTQE SRL 1183 |
Gene Ontology | GO:0005829; C:cytosol; IDA:RGD. GO:0031680; C:G-protein beta/gamma-subunit complex; IDA:RGD. GO:0005794; C:Golgi apparatus; IDA:RGD. GO:0005886; C:plasma membrane; IDA:RGD. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0031683; F:G-protein beta/gamma-subunit complex binding; IDA:RGD. GO:0004435; F:phosphatidylinositol phospholipase C activity; NAS:UniProtKB. GO:0005543; F:phospholipid binding; IDA:RGD. GO:0004871; F:signal transducer activity; IDA:UniProtKB. GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB. GO:0035556; P:intracellular signal transduction; IDA:UniProtKB. GO:0009395; P:phospholipid catabolic process; NAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |