UniProt Accession

 ADK_YEAST; P47143; D6VWS4 

Genbank Protein ID

 Z49605; AY558082; BK006943 

Genbank Nucleotide ID

 CAA89635.1; AAS56408.1; DAA08890.1 

Protein Name

 Adenosine kinase 

Protein Synonyms/Alias

  

Gene Name

 ADO1 

Gene Synonyms/Alias

 YJR105W; J1973 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
30	YLAKYSLKENDAILV	ubiquitination	[1]
40	DAILVDAKSGDAKMA	acetylation	[2]
40	DAILVDAKSGDAKMA	ubiquitination	[1]
45	DAKSGDAKMAIFDEL	ubiquitination	[1]
103	RLLNENEKAGVKSMY	acetylation	[2]
107	ENEKAGVKSMYQVQN	ubiquitination	[1]
120	QNDIGTGKCAALITG	ubiquitination	[1]
247	AIAQRIVKDSPVEKT	acetylation	[2]
247	AIAQRIVKDSPVEKT	ubiquitination	[1]
270	PTVVVSSKGTSTYPV	ubiquitination	[1]
278	GTSTYPVKPLDSSKI	acetylation	[2]
278	GTSTYPVKPLDSSKI	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. ADO1 does not play a major role in adenine utilization in yeast. Its physiological role could primarily be to recycle adenosine produced by the methyl cycle. 

Sequence Annotation

 ACT_SITE 293 293 By similarity.  

Keyword

 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Purine salvage; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 340 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004001; F:adenosine kinase activity; IMP:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
 GO:0006144; P:purine nucleobase metabolic process; IMP:SGD.
 GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW. 

Interpro

 IPR001805; Adenokinase.
 IPR002173; Carboh/pur_kinase_PfkB_CS.
 IPR011611; PfkB_dom. 

Pfam

 PF00294; PfkB 

SMART

  

PROSITE

 PS00583; PFKB_KINASES_1
 PS00584; PFKB_KINASES_2 

PRINTS

 PR00989; ADENOKINASE.