UniProt Accession

 MTHFS_MYCPN; P75430 

Genbank Protein ID

 U00089 

Genbank Nucleotide ID

 AAB96136.1 

Protein Name

 Probable 5-formyltetrahydrofolate cyclo-ligase 

Protein Synonyms/Alias

 5,10-methenyl-tetrahydrofolate synthetase; MTHFS; Methenyl-THF synthetase 

Gene Name

 MPN_348; H91_orf164, MP488 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 

NCBI Taxa ID

 272634 

Lysine Modification

Position	Peptide	Type	References
120	NYRLGFGKGYYDRYL	acetylation	[1]

Reference

 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 

Functional Description

  

Sequence Annotation

 NP_BIND 3 7 ATP.
 NP_BIND 117 125 ATP.
 REGION 118 122 Substrate binding.
 BINDING 55 55 Substrate.
 BINDING 115 115 Substrate.
 BINDING 154 154 ATP.  

Keyword

 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 164 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030272; F:5-formyltetrahydrofolate cyclo-ligase activity; IEA:EC.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro. 

Interpro

 IPR002698; FTHF_cligase.
 IPR024185; FTHF_cligase-like. 

Pfam

 PF01812; 5-FTHF_cyc-lig 

SMART

  

PROSITE

  

PRINTS