CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042454
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rap guanine nucleotide exchange factor 1 
Protein Synonyms/Alias
  
Gene Name
 RAPGEF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
111IMSRLTLKQEGDDGPubiquitination[1]
163SPEELIKKLQYRYEKubiquitination[1]
241LDKVDQKKLLRCATSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 319 AA 
Protein Sequence
XLAPPPALPP KQRQLSENAS EEAGEGEYVN LYSSGQSSEE LAPSRGEPPA GKDGHPRDPS 60
AVSGVPGKDS RDGSERAPKS PDALESAQSE EEVDELSLID HNEIMSRLTL KQEGDDGPDV 120
RGGSGDILLV HATETDRKDL VLYCEAFLTT YRTFISPEEL IKKLQYRYEK FSPFADTFKK 180
RVSKNTFFVL VRVVDELCLV ELTEEILKLL MELVFRLVCN GELSLARVLR KNILDKVDQK 240
KLLRCATSSQ PLAARGVAAR PGTLHDFHSH EIAEQLTLLD AELFYKIEIP EVLLWAKEQN 300
EEKSPNLTQF TEHFNNMSY 319 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR000651; Ras-like_Gua-exchang_fac_N.
 IPR023578; Ras_GEF_dom.
 IPR001895; RasGRF_CDC25. 
Pfam
 PF00617; RasGEF
 PF00618; RasGEF_N 
SMART
 SM00229; RasGEFN 
PROSITE
 PS50009; RASGEF_CAT
 PS50212; RASGEF_NTER 
PRINTS