UniProt Accession

 SGMR1_HUMAN; Q99720; D3DRM7; O00673; O00725; Q0Z9W6; Q153Z1; Q2TSD1; Q53GN2; Q7Z653; Q8N7H3; Q9NYX0 

Genbank Protein ID

 U75283; U79528; AF001977; AF001976; AF226604; AY633611; DQ644568; DQ647702; DQ656583; AK098451; CR457075; AK222899; AL450283; CH471071; CH471071; BC004899; BC007839 

Genbank Nucleotide ID

 AAB50402.1; AAB51238.1; AAC04507.1; AAC04507.1; AAF64280.1; AAV33304.1; ABG29111.1; ABG36559.1; ABG46369.1; BAC05307.1; CAG33356.1; BAD96619.1; CAI14185.1; EAW58431.1; EAW58434.1; AAH04899.1; AAH07839.1 

Protein Name

 Sigma non-opioid intracellular receptor 1 

Protein Synonyms/Alias

 Aging-associated gene 8 protein; SR31747-binding protein; SR-BP; Sigma 1-type opioid receptor; SIG-1R; Sigma1-receptor; Sigma1R; hSigmaR1 

Gene Name

 SIGMAR1 

Gene Synonyms/Alias

 OPRS1; SRBP; AAG8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
122	QWREGTTKSEVFYPG	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. 

Sequence Annotation

 REGION 2 8 Targeting to lipid droplets (By
 REGION 118 148 Mediates ligand-binding.  

Keyword

 Alternative splicing; Amyotrophic lateral sclerosis; Cell junction; Cell membrane; Cell projection; Complete proteome; Direct protein sequencing; Disease mutation; Endoplasmic reticulum; Lipid droplet; Lipid transport; Membrane; Neurodegeneration; Nucleus; Polymorphism; Receptor; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 223 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005811; C:lipid particle; IEA:UniProtKB-SubCell.
 GO:0005635; C:nuclear envelope; IDA:UniProtKB.
 GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
 GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
 GO:0000247; F:C-8 sterol isomerase activity; IEA:InterPro.
 GO:0008144; F:drug binding; TAS:ProtInc.
 GO:0004985; F:opioid receptor activity; IEA:Compara.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0006696; P:ergosterol biosynthetic process; IEA:InterPro.
 GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
 GO:0007399; P:nervous system development; IEA:Compara.
 GO:0043523; P:regulation of neuron apoptotic process; IMP:UniProtKB. 

Interpro

 IPR006716; ERG2_sigma1_rcpt-like. 

Pfam

 PF04622; ERG2_Sigma1R 

SMART

  

PROSITE

  

PRINTS