CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019074
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleus accumbens-associated protein 2 
Protein Synonyms/Alias
 NAC-2; BTB/POZ domain-containing protein 14A 
Gene Name
 NACC2 
Gene Synonyms/Alias
 BTBD14A; NAC2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
299GSYAVQEKPEPVPLEubiquitination[1]
456KRWLPKIKSMLPEGVubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
 DOMAIN 30 94 BTB.
 DOMAIN 351 448 BEN.  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 587 AA 
Protein Sequence
MSQMLHIEIP NFGNTVLGCL NEQRLLGLYC DVSIVVKGQA FKAHRAVLAA SSLYFRDLFS 60
GNSKSAFELP GSVPPACFQQ ILSFCYTGRL TMTASEQLVV MYTAGFLQIQ HIVERGTDLM 120
FKVSSPHCDS QTAVIEDAGS EPQSPCNQLQ PAAAAAAPYV VSPSVPIPLL TRVKHEAMEL 180
PPAGPGLAPK RPLETGPRDG VAVAAGAAVA AGTAPLKLPR VSYYGVPSLA TLIPGIQQMP 240
YPQGERTSPG ASSLPTTDSP TSYHNEEDEE DDEAYDTMVE EQYGQMYIKA SGSYAVQEKP 300
EPVPLESRSC VLIRRDLVAL PASLISQIGY RCHPKLYSEG DPGEKLELVA GSGVYITRGQ 360
LMNCHLCAGV KHKVLLRRLL ATFFDRNTLA NSCGTGIRSS TSDPSRKPLD SRVLNAVKLY 420
CQNFAPSFKE SEMNVIAADM CTNARRVRKR WLPKIKSMLP EGVEMYRTVM GSAAASVPLD 480
PEFPPAAAQV FEQRIYAERR GDAATIVALR TDAVNVDLSA AANPAFDAGE EVDGAGSVIQ 540
EVAAPEPLPA DGQSPPQPFE QGGGGPSRPQ TPAAAARRPE GTYAGTL 587 
Gene Ontology
 GO:0016604; C:nuclear body; ISS:UniProtKB.
 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0004407; F:histone deacetylase activity; IDA:BHF-UCL.
 GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:BHF-UCL.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IDA:BHF-UCL.
 GO:0001076; F:RNA polymerase II transcription factor binding transcription factor activity; IDA:BHF-UCL.
 GO:0034629; P:cellular protein complex localization; IDA:BHF-UCL.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IDA:BHF-UCL.
 GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL.
 GO:1900477; P:negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
 GO:0010608; P:posttranscriptional regulation of gene expression; IMP:BHF-UCL.
 GO:0051260; P:protein homooligomerization; ISS:UniProtKB. 
Interpro
 IPR018379; BEN_domain.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ. 
Pfam
 PF10523; BEN
 PF00651; BTB 
SMART
 SM01025; BEN
 SM00225; BTB 
PROSITE
 PS51457; BEN
 PS50097; BTB 
PRINTS