Tag | Content |
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CPLM ID | CPLM-024622 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcriptional repressor NF-X1 |
Protein Synonyms/Alias | m-Nfx.1; Nuclear transcription factor, X box-binding protein 1 |
Gene Name | Nfx1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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91 | GFFQSSNKSLKNHGL | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. |
Sequence Annotation | DOMAIN 988 1056 R3H. ZN_FING 352 403 RING-type; atypical. ZN_FING 447 465 NF-X1-type 1. ZN_FING 500 519 NF-X1-type 2. ZN_FING 561 580 NF-X1-type 3. ZN_FING 626 649 NF-X1-type 4. ZN_FING 688 707 NF-X1-type 5. ZN_FING 715 734 NF-X1-type 6. ZN_FING 826 848 NF-X1-type 7. ZN_FING 857 878 NF-X1-type 8. REGION 9 26 Interaction with PABPC1 and PABC4 (By MOD_RES 50 50 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; DNA-binding; Ligase; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1114 AA |
Protein Sequence | MAEAPPVSGT FKFNTDAAEF IPQERKTSGL NCGTQRRLDS SRIGRRNYSS SPPCHLPRHI 60 PYEDISAVHQ HSYASGSKPK SPQGFFQSSN KSLKNHGLQN QPWQKARNEK HQNRNKKAQG 120 LSEQTSDTSS LESVARSESG TNPREHSPSE SEKEVVIADP RGAKPKKAAQ LTYNYGRGPK 180 AKGRLRSEWG NRMSPKSEDE NTRPVAISHT DSSDASCRKP VVDPCVCRRN EQRRYPQKRP 240 PWEVEGARPR PGRNPPKQES QRHINAGPKT NMSPIPKDNL RERPTKSACD TGNLAVVSKS 300 SRRVNQEKTA VRRQDPQVLS PFPRGKQNHM LKNVETHTGS LIEQLTTEKY ECMVCCELVQ 360 VTAPVWSCQS CFHVFHLNCI KKWARSPASH ADGQSGWRCP ACQNVSAHVP NTYTCFCGKV 420 KNPEWSRNEI PHSCGEVCRK KQPGQDCPHS CNLLCHPGPC PPCPAFTTKT CECGRTRHTV 480 RCGQPVSVHC SNACENILNC GQHHCAELCH GGQCQPCRII LNQVCYCGST SRDVLCGTDV 540 GKSDGFGDFS CLKICGKDLK CGSHTCSQVC HPQPCQPCPR LPHLVRYCPC GQTPLSQLLE 600 HGSNARKTCM DPVPSCGKVC GKPLACGSSD FIHTCEKLCH EGDCGPCSRT SVISCRCSFR 660 TKELPCTSLK SEDATFMCDK RCNKKRLCGR HKCNEICCVD KEHKCPLICG RKLRCGLHRC 720 EEPCHRGNCQ TCWQASFDEL TCHCGASVIY PPVPCGTRPP ECTQTCARIH ECDHPVYHSC 780 HSEEKCPPCT FLTQKWCMGK HELRSNIPCH LVDISCGLPC SAMLPCGMHK CQRLCHKGEC 840 LVDEACKQPC TTPRGDCGHP CMAPCHPSLP CPVTACKAKV ELQCECGRRK EMVICSEASG 900 TYQRIVAISM ASKITDMQLG DSVEISKLIT KKEVQQARLQ CDEECAALER RKRLAEAFDI 960 TDDSDPFNVR SSASKFSDSL KDDARKDLKF VSDVEKEMET LVEAVNKGKN NKKSHCFPPM 1020 NRDHRRIIHD LAQVYGLESI SYDSEPKRNV VVTAVRGKSV CPPTTLTSVI ERETQTRPPP 1080 PIPHHRHQAD KAPGSSTLQK IVKEAVIDYF DVQD 1114 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0045347; P:negative regulation of MHC class II biosynthetic process; IDA:MGI. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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PROSITE | |
PRINTS | |