CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007892
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleoporin NUP192 
Protein Synonyms/Alias
 Nuclear pore protein NUP192 
Gene Name
 NUP192 
Gene Synonyms/Alias
 YJL039C; J1216 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
1425SDQVGSEKVLQDLRLubiquitination[1]
1668QSLNEMVKLIVMLCTubiquitination[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 
Functional Description
 Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP192 is located to the NPC core at the nuclear membrane and is essential for de novo assembly of NPCs. 
Sequence Annotation
  
Keyword
 3D-structure; Coiled coil; Complete proteome; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1683 AA 
Protein Sequence
MKWSAIPFQT LYRSIESGEF DFDLFKEVLP DLQNLNLNTD KLKNNASRSQ LEKGEIELSD 60
GSTFKVNQEF IFEAISLSDE LNLDEIVACE LILSGDTTAN NGKVQYFLRR QYILQIVSFI 120
VNCFHEDTEL YQELIKNGAL VSNILSAFKF IHTQLSEIKQ QINKAQILEN YNALFQQNIK 180
FRRDFLLREY DILSQILYGL VDKGAIMKNK DFILSLLHHV SELDSNDFFI IYYTPAFFHL 240
FASLRVLPDA DVKLLHSQFM KDLKDDSIYT KPVKVALIFI FFAYFIGWCK EDPKRRADTM 300
DFKTDVDEPM TSAVELGAIE QILIFAADTS IVEQDKSMEL FYDIRSLLER HIPRLIPKQL 360
LDDEKIFSQT TNSTYNPASA TDNMSGRGLW NPSYPGMMST TGTARLNSMP NNVNEYSYTT 420
IVLSDQTQEF FLSSFDDVLQ TIITDCAFLL TKIKDAEEDS LLSGEDLTLD DISLKADLER 480
FFLSIYFFYA SRPEYSCTFW SDKESNAYGF IEWCSRCNDN LMRSCFYLMV SSLSFGPENA 540
LNVYHYFGEN SSISWKNIAQ CLSDYTKKIS NFNSSLHKRQ QFSESTHNDI DSTAVALEEG 600
LNEEAVIFLS SLLTLVGSVT YQVDEDVKSS LSKVFSDVLF EFTKINTPLV GAAFKVISNL 660
VPKLESSRTK FWSFLDSLIF KDSSLNYSSE SYRNAFTNVL TKYSDVLGFL QLFHNLISIH 720
SRENNSEYMV FGKLAFPTRL GQGYRKVGIW PYFDYIFNDI LAHVDQIVDI RNKRAVQLPI 780
LKIIYTGLCS FDYSVILNSI PAAANLDALV DCENFFNYVQ ECPAIPIFNY IFTEKIYKSI 840
FNVVDVGVDQ LSIELEGGKN QAELLQLAVK IINKVLDYQE TYVEELFPIV KKHGKTDYFL 900
PKNYSLHGLR SFYDAIFFNI PLVAHLGLYV GVDDQILATN SLRILAKLSE RSNGSVASLS 960
KRNKLLTIFD SVDESARIKD AFITQLESSI TDAGVLALKL ELLDFLTSNL SNYSRTMTIS 1020
HLLLGFQVSN VISLGPNLAT FISSGTSLLD SLISVLEASL NSITKDNIDY APMRLATAAL 1080
EIILKLCRNP LTSGLLYSYL IKENFFERIM ILDPQVTRFT TWNGSPFDNS TEEKCKNFIE 1140
SESVGAFLSF LAYRNYWTQY LGLFIHKISF SGTKSEVLTY VNYLISNTMY SVRLFSFLDP 1200
LNYGNICEPK ETLSIFTNVP LNLEQVTLNK YCSGNIYDFH KMENLMRLIK RVRAESLHSN 1260
SFSLTVSKEQ FLKDADVECI KAKSHFTNII SRNKALELNL SVLHSWVQLV QIIVTDGKLE 1320
PSTRSNFILE VFGTIIPKIS DYIEFNITFS EELVSLAVFL FDIYNRDRKL ITDKGTVDGR 1380
LYQLFKTCIQ GINSPLSSVA LRSDFYILAN HYLSRVLSDQ VGSEKVLQDL RLGSKKLVEI 1440
IWNDVVYGEG TSRVTGILLL DSLIQLANRS KENFILDSLM KTTRLLLIIR SLKNTDALLN 1500
STTEHINIDD LLYELTAFKA TVFFLIRVAE TRGGASALIE NNLFRIIAEL SFLKVDPDLG 1560
LDLMFDEVYV QNSKFLKVNV TLDNPLLVDK DANGVSLFEL IVPIFQLISA VLVSMGSSNK 1620
AVVQTVKGLL NTYKRLVIGI FKRDLLREKE DKKNSSDPNN QSLNEMVKLI VMLCTLTGYQ 1680
NND 1683 
Gene Ontology
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0044611; C:nuclear pore inner ring; IDA:SGD.
 GO:0044615; C:nuclear pore nuclear basket; IDA:SGD.
 GO:0017056; F:structural constituent of nuclear pore; IMP:SGD.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0006999; P:nuclear pore organization; IMP:SGD.
 GO:0006913; P:nucleocytoplasmic transport; IC:SGD.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR021827; Nup186/Nup192/Nup205. 
Pfam
 PF11894; DUF3414 
SMART
  
PROSITE
  
PRINTS