CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029135
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sorting nexin 1, isoform CRA_d 
Protein Synonyms/Alias
 Sorting nexin-1 
Gene Name
 SNX1 
Gene Synonyms/Alias
 hCG_33348 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
196DFLGLYEKLSEKHSQubiquitination[1]
200LYEKLSEKHSQNGFIubiquitination[1]
214IVPPPPEKSLIGMTKubiquitination[1]
221KSLIGMTKVKVGKEDubiquitination[1]
223LIGMTKVKVGKEDSSubiquitination[1]
237SSAEFLEKRRAALERacetylation[2, 3]
267DVREFLEKEELPRAVubiquitination[1, 4, 5]
286LSGAGLLKMFNKATDubiquitination[1, 4]
290GLLKMFNKATDAVSKubiquitination[1]
297KATDAVSKMTIKMNEubiquitination[1]
325CEEQRLRKLHAVVETubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 474 AA 
Protein Sequence
MASGGGGCSA SERLPPPFPG LEPESEGAAG GSEPEAGDSD TEGEDIFTGA AVVSKHQSPK 60
ITTSLLPINN GSKENGIHEE QDQEPQDLFA DATVELSLDS TQNNQKKVLA KTLISLPPQE 120
ATNSSKPQPT YEELEEEEQE DQFDLTVGIT DPEKIGDGMN AYVAYKVTTQ TSLPLFRSKQ 180
FAVKRRFSDF LGLYEKLSEK HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA 240
ALERYLQRIV NHPTMLQDPD VREFLEKEEL PRAVGTQTLS GAGLLKMFNK ATDAVSKMTI 300
KMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTAQFAKS LAMLGSSEDN 360
TALSRALSQL AEVEEKIEQL HQEQANNDFF LLAELLSDYI RLLAIVRWES RVTQYERDFE 420
RISTVVRKEV IRFEKEKSKD FKNHVIKYLE TLLYSQQQLA KYWEAFLPEA KAIS 474 
Gene Ontology
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR001683; Phox.
 IPR005329; Sorting_nexin_N.
 IPR015404; Vps5_C. 
Pfam
 PF00787; PX
 PF03700; Sorting_nexin
 PF09325; Vps5 
SMART
 SM00312; PX 
PROSITE
 PS50195; PX 
PRINTS