CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028636
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Copper-transporting ATPase 1 
Protein Synonyms/Alias
  
Gene Name
 Atp7a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
333VTPEMLRKAIEAISPubiquitination[1]
729YFYIQAYKALKHKTAacetylation[2]
876EAMPVAKKPGSTVIAubiquitination[1]
1059KVLVESNKISRNKILubiquitination[1]
1128LLHKSNLKIEENNIKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1492 AA 
Protein Sequence
MEPSVDANSI TITVEGMTCI SCVRTIEQQI GKVNGVHHIK VSLEEKSATI IYDPKLQTPK 60
TLQEAIDDMG FDALLHNANP LPVLTNTVFL TVTAPLTLPW DHIQSTLLKT KGVTGVKISP 120
QQRSAVVTII PSVVSASQIV ELVPDLSLDM GTQEKKSGAC EEHSTPQAGE VMLKMKVEGM 180
TCHSCTSTIE GKVGKLQGVQ RIKVSLDNQE ATIVFQPHLI TAEEIKKQIE AVGFPAFIKK 240
QPKYLKLGAI DVERLKNTPV KSSEGSQQKS PSYPSDSTTM FTIEGMHCKS CVSNIESALS 300
TLQYVSSIVV SLENRSAIVK YNASLVTPEM LRKAIEAISP GQYRVSIASE VESTASSPSS 360
SSLQKMPLNI VSQPLTQEAV ININGMTCNS CVQSIEGVIS KKPGVKSIHV SLANSTGTIE 420
FDPLLTSPET LREAIEDMGF DAALPADMKE PLVVIAQPSL ETPLLPSSNE LENVMTSVQN 480
KCYIQVSGMT CASCVANIER NLRREEGIYS VLVALMAGKA EVRYNPAVIQ PRVIAEFIRE 540
LGFGAMVMEN AGEGNGILEL VVRGMTCASC VHKIESTLTK HKGIFYCSVA LATNKAHIKY 600
DPEIIGPRDI IHTIGSLGFE ASLVKKDRSA NHLDHKREIK QWRGSFLVSL FFCIPVMGLM 660
VYMMVMDHHL ATLHHNQNMS NEEMINMHSA MFLERQILPG LSIMNLLSLL LCLPVQFCGG 720
WYFYIQAYKA LKHKTANMDV LIVLATTIAF AYSLVILLVA MFERAKVNPI TFFDTPPMLF 780
VFIALGRWLE HIAKGKTSEA LAKLISLQAT EATIVTLNSE NLLLSEEQVD VELVQRGDII 840
KVVPGGKFPV DGRVIEGHSM VDESLITGEA MPVAKKPGST VIAGSINQNG SLLIRATHVG 900
ADTTLSQIVK LVEEAQTSKA PIQQFADKLS GYFVPFIVLV SIVTLLVWII IGFQNFEIVE 960
TYFPGYNRSI SRTETIIRFA FQASITVLCI ACPCSLGLAT PTAVMVGTGV GAQNGILIKG 1020
GEPLEMAHKV KVVVFDKTGT ITHGTPVVNQ VKVLVESNKI SRNKILAIVG TAESNSEHPL 1080
GAAVTKYCKK ELDTETLGTC TDFQVVPGCG ISCKVTNIEG LLHKSNLKIE ENNIKNASLV 1140
QIDAINEQSS TSSSMIIDAH LSNAVNTQQY KVLIGNREWM IRNGLVISND VDESMIEHER 1200
RGRTAVLVTI DDELCGLIAI ADTVKPEAEL AVHILKSMGL EVVLMTGDNS KTARSIASQV 1260
GITKVFAEVL PSHKVAKVKQ LQEEGKRVAM VGDGINDSPA LAMANVGIAI GTGTDVAIEA 1320
ADVVLIRNDL LDVVASIDLS RKTVKRIRIN FVFALIYNLV GIPIAAGVFL PIGLVLQPWM 1380
GSAAMAASSV SVVLSSLFLK LYRKPTYDNY ELHPRSHTGQ RSPSEISVHV GIDDTSRNSP 1440
RLGLLDRIVN YSRASINSLL SDKRSLNSVV TSEPDKHSLL VGDFREDDDT TL 1492 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0031526; C:brush border membrane; IEA:Compara.
 GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:Compara.
 GO:0005770; C:late endosome; IEA:Compara.
 GO:0043005; C:neuron projection; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0030141; C:secretory granule; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IDA:MGI.
 GO:0030140; C:trans-Golgi network transport vesicle; IEA:Compara.
 GO:0004008; F:copper-exporting ATPase activity; IDA:MGI.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0016532; F:superoxide dismutase copper chaperone activity; IDA:MGI.
 GO:0001568; P:blood vessel development; IMP:MGI.
 GO:0001974; P:blood vessel remodeling; IMP:MGI.
 GO:0051216; P:cartilage development; IMP:MGI.
 GO:0006878; P:cellular copper ion homeostasis; IMP:MGI.
 GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:MGI.
 GO:0030199; P:collagen fibril organization; IMP:MGI.
 GO:0015677; P:copper ion import; IMP:MGI.
 GO:0048813; P:dendrite morphogenesis; IMP:MGI.
 GO:0010273; P:detoxification of copper ion; IMP:MGI.
 GO:0042417; P:dopamine metabolic process; IMP:MGI.
 GO:0048251; P:elastic fiber assembly; IMP:MGI.
 GO:0051542; P:elastin biosynthetic process; IMP:MGI.
 GO:0042414; P:epinephrine metabolic process; IMP:MGI.
 GO:0031069; P:hair follicle morphogenesis; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0048286; P:lung alveolus development; IMP:MGI.
 GO:0048553; P:negative regulation of metalloenzyme activity; IMP:MGI.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.
 GO:0042421; P:norepinephrine biosynthetic process; IMP:MGI.
 GO:0018205; P:peptidyl-lysine modification; IMP:MGI.
 GO:0043473; P:pigmentation; IMP:MGI.
 GO:0048554; P:positive regulation of metalloenzyme activity; IMP:MGI.
 GO:0051353; P:positive regulation of oxidoreductase activity; IEA:Compara.
 GO:0021860; P:pyramidal neuron development; IMP:MGI.
 GO:0010468; P:regulation of gene expression; IMP:MGI.
 GO:0002082; P:regulation of oxidative phosphorylation; IMP:MGI.
 GO:0001836; P:release of cytochrome c from mitochondria; IMP:MGI.
 GO:0019430; P:removal of superoxide radicals; IMP:MGI.
 GO:0010041; P:response to iron(III) ion; IEA:Compara.
 GO:0010043; P:response to zinc ion; IEA:Compara.
 GO:0042428; P:serotonin metabolic process; IMP:MGI.
 GO:0043588; P:skin development; IMP:MGI.
 GO:0042093; P:T-helper cell differentiation; IMP:MGI.
 GO:0006568; P:tryptophan metabolic process; IMP:MGI.
 GO:0006570; P:tyrosine metabolic process; IMP:MGI. 
Interpro
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR027256; Cation_transp_P-typ_ATPase_IB.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom.
 IPR017969; Heavy-metal-associated_CS.
 IPR006121; HeavyMe-assoc_HMA.
 IPR006122; HMA_Cu_ion-bd. 
Pfam
 PF00122; E1-E2_ATPase
 PF00403; HMA
 PF00702; Hydrolase 
SMART
  
PROSITE
 PS00154; ATPASE_E1_E2
 PS01047; HMA_1
 PS50846; HMA_2 
PRINTS
 PR00119; CATATPASE.