UniProt Accession

 VIE1_HCMVT; P03169; Q00677 

Genbank Protein ID

 M11630; M11628; M11629; M60321 

Genbank Nucleotide ID

 AAA45979.1; AAA45979.1; AAA45979.1; AAA45982.1 

Protein Name

 55 kDa immediate-early protein 1 

Protein Synonyms/Alias

 IE1 

Gene Name

 UL123 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5) 

NCBI Taxa ID

 10363 

Lysine Modification

Position	Peptide	Type	References
450	REDTVSVKSEPVSEI	sumoylation	[1, 2]

Reference

 [1] SUMO-1 modification of human cytomegalovirus IE1/IE72.
 Spengler ML, Kurapatwinski K, Black AR, Azizkhan-Clifford J.
 J Virol. 2002 Mar;76(6):2990-6. [PMID: 11861864]
 [2] SUMO-1 modification of the major immediate-early (IE) 1 and 2 proteins of human cytomegalovirus is regulated by different mechanisms and modulates the intracellular localization of the IE1, but not IE2, protein.
 Sadanari H, Yamada R, Ohnishi K, Matsubara K, Tanaka J.
 Arch Virol. 2005 Sep;150(9):1763-82. [PMID: 15931461] 

Functional Description

 Plays an important role in transactivating viral early genes as well as activating its own promoter. Targets and disrupts host PML/nuclear domain 10 (ND10). Promotes efficient viral growth by interacting with and directing host SP100 to degradation, leading to enhanced acetylation level of histones. In addition, functions in counteracting the host innate antiviral response. Inhibits the type I interferon pathway by directly interacting with and sequestrating host STAT2. Alters host cell cycle progression, probably through its interaction with host E2F1 or RB1 that overcomes the RB1-mediated repression of E2F-responsive promoters. 

Sequence Annotation

 REGION 475 491 Chromosome-tethering domain (CTD).
 CROSSLNK 450 450 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Early protein; G1/S host cell cycle checkpoint dysregulation by virus; Host nucleus; Host-virus interaction; Inhibition of host innate immune response by virus; Inhibition of host interferon signaling pathway by virus; Isopeptide bond; Modulation of host cell cycle by virus; Phosphoprotein; Ubl conjugation; Viral immunoevasion. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 491 AA 

Protein Sequence

Gene Ontology

 GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
 GO:0039645; P:modulation by virus of host G1/S transition checkpoint; IEA:UniProtKB-KW.
 GO:0050792; P:regulation of viral reproduction; IEA:InterPro.
 GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR010855; Cytomega_IE1. 

Pfam

 PF07340; Herpes_IE1 

SMART

  

PROSITE

  

PRINTS