CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037157
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Amiloride-sensitive sodium channel subunit alpha 
Protein Synonyms/Alias
  
Gene Name
 SCNN1A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
233FQLCNQNKSDCFYQTubiquitination[1]
551AKVNIFFKELNYKTNubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 691 AA 
Protein Sequence
MEGNKLEEQD SSPPQSTPGL MKGNKREEQG LGPEPAAPQQ PTAEEEALIE FHRSYRELFE 60
FFCNNTTIHG AIRLVCSQHN RMKTAFWAVL WLCTFGMMYW QFGLLFGEYF SYPVSLNINL 120
NSDKLVFPAV TICTLNPYRY PEIKEELEEL DRITEQTLFD LYKYSSFTTL VAGSRSRRDL 180
RGTLPHPLQR LRVPPPPHGA RRARSVASSL RDNNPQVDWK DWKIGFQLCN QNKSDCFYQT 240
YSSGVDAVRE WYRFHYINIL SRLPETLPSL EEDTLGNFIF ACRFNQVSCN QANYSHFHHP 300
MYGNCYTFND KNNSNLWMSS MPGINNGLSL MLRAEQNDFI PLLSTVTGAR VMVHGQDEPA 360
FMDDGGFNLR PGVETSISMR KETLDRLGGD YGDCTKNGSD VPVENLYPSK YTQQVCIHSC 420
FQESMIKECG CAYIFYPRPQ NVEYCDYRKH SSWGQVRSLT PVIPALWEAE AGRSRGYCYY 480
KLQVDFSSDH LGCFTKCRKP CSVTSYQLSA GYSRWPSVTS QEWVFQMLSR QNNYTVNNKR 540
NGVAKVNIFF KELNYKTNSE SPSVTMVTLL SNLGSQWSLW FGSSVLSVVE MAELVFDLLV 600
IMFLMLLRRF RSRYWSPGRG GRGAQEVAST LASSPPSHFC PHPMSLSLSQ PGPAPSPALT 660
APPPAYATLG PRPSPGGSAG ASSSTCPLGG P 691 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
 GO:0035725; P:sodium ion transmembrane transport; IEA:GOC. 
Interpro
 IPR004724; EnaC.
 IPR001873; Na+channel_ASC.
 IPR020903; Na+channel_ASC_CS. 
Pfam
 PF00858; ASC 
SMART
  
PROSITE
 PS01206; ASC 
PRINTS
 PR01078; AMINACHANNEL.