| Tag | Content |
|---|
| CPLM ID | CPLM-016059 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aldehyde dehydrogenase family 3 member B1 |
Protein Synonyms/Alias | Aldehyde dehydrogenase 7 |
Gene Name | Aldh3b1 |
Gene Synonyms/Alias | Aldh7 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 148 | EISKATEKILAEVLP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Oxidizes medium and long chain saturated and unsaturated aldehydes (By similarity). Metabolizes also benzaldehyde (By similarity). Low activity towards acetaldehyde and 3,4- dihydroxyphenylacetaldehyde (By similarity). May not metabolize short chain aldehydes (By similarity). May use both NADP(+) and NAD(+) as cofactors (By similarity). May have a protective role against the cytotoxicity induced by lipid peroxidation (By similarity). |
Sequence Annotation | NP_BIND 188 193 NAD (By similarity).
ACT_SITE 210 210 By similarity.
ACT_SITE 244 244 By similarity. |
Keyword | Complete proteome; NAD; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 468 AA |
Protein Sequence | MDSFEDKLQQ LREAFKEGRT RSAEFRAAQL QGLSHFLRDN KQQLQEALAQ DLHKSAFEAE 60
VSEIAISQAE VDLALRNLRS WMKDEKVSKN LATQLDSAFI RKEPFGLVLI IVPWNYPINL 120
TLVPLVGAIA AGNCVVLKPS EISKATEKIL AEVLPRYLDQ SCFTVVLGGR QETGQLLEHK 180
FDYIFFTGNA YVGKIVMAAA AKHLTPITLE LGGKNPCYVD DNCDPQIVAN RVAWFRYFNA 240
GQTCVAPDYI LCSQEMQERL VPALQNAITR FYGDNPQTSP NLGRIINQKH FKRLQGLLGC 300
GRVAIGGQSD EGERYIAPTV LVDVQETEPV MQEEIFGPIL PLVTVRSLDE AIEFMNRREK 360
PLALYAFSKR SQVIKQVLAR TSSGGFCGND GFMHMTLSSL PFGGVGTSGM GRYHGKFSFD 420
TFSNQRACLL RSPGMEKIND LRYPPYSSRN LRVLLVAMEE RCCSCTLL 468 |
Gene Ontology | GO:0005829; C:cytosol; IDA:MGI. GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; ISO:MGI. GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro. GO:0006068; P:ethanol catabolic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |