UniProt Accession

 SERB_RAT; Q5M819 

Genbank Protein ID

 BC088310 

Genbank Nucleotide ID

 AAH88310.1 

Protein Name

 Phosphoserine phosphatase 

Protein Synonyms/Alias

 PSP; PSPase; O-phosphoserine phosphohydrolase 

Gene Name

 Psph 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
168	VIGFLKEKFHFKKII	acetylation	[1]
172	LKEKFHFKKIIMIGD	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity). 

Sequence Annotation

 REGION 109 110 Substrate binding (By similarity).
 ACT_SITE 20 20 Nucleophile (By similarity).
 ACT_SITE 22 22 Proton donor (By similarity).
 METAL 20 20 Magnesium (By similarity).
 METAL 22 22 Magnesium; via carbonyl oxygen (By
 METAL 179 179 Magnesium (By similarity).
 BINDING 29 29 Substrate (By similarity).
 BINDING 65 65 Substrate (By similarity).
 BINDING 158 158 Substrate (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 Acetylation; Amino-acid biosynthesis; Complete proteome; Hydrolase; Magnesium; Metal-binding; Phosphoprotein; Reference proteome; Serine biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 225 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0005509; F:calcium ion binding; ISS:UniProtKB.
 GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
 GO:0004647; F:phosphoserine phosphatase activity; ISS:UniProtKB.
 GO:0006564; P:L-serine biosynthetic process; IBA:RefGenome.
 GO:0009612; P:response to mechanical stimulus; IEP:RGD.
 GO:0031667; P:response to nutrient levels; IEP:RGD.
 GO:0033574; P:response to testosterone stimulus; IEP:RGD. 

Interpro

 IPR023214; HAD-like_dom.
 IPR006383; HAD-SF_hydro_IB_PSP-like.
 IPR023190; Pser_Pase_dom_2.
 IPR004469; SerB. 

Pfam

  

SMART

  

PROSITE

  

PRINTS