UniProt Accession

 ATF2_RAT; Q00969; Q62870 

Genbank Protein ID

 M65148; U38938 

Genbank Nucleotide ID

 AAA42013.1; AAA93263.1 

Protein Name

 Cyclic AMP-dependent transcription factor ATF-2 

Protein Synonyms/Alias

 cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; cAMP response element-binding protein CRE-BP1 

Gene Name

 Atf2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
87	KASEDDIKKMPLDLS	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex. 

Sequence Annotation

 DOMAIN 334 397 bZIP.
 ZN_FING 7 31 C2H2-type.
 REGION 336 356 Basic motif (By similarity).
 REGION 362 390 Leucine-zipper (By similarity).
 MOD_RES 51 51 Phosphothreonine; by MAPK11 and MAPK14
 MOD_RES 53 53 Phosphothreonine; by MAPK1, MAPK3,
 MOD_RES 72 72 Phosphoserine (By similarity).
 MOD_RES 94 94 Phosphoserine (By similarity).
 MOD_RES 98 98 Phosphothreonine (By similarity).
 MOD_RES 310 310 Phosphoserine (By similarity).  

Keyword

 Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 487 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:Compara.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0035497; F:cAMP response element binding; IDA:RGD.
 GO:0008140; F:cAMP response element binding protein binding; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0060612; P:adipose tissue development; IEA:Compara.
 GO:0045444; P:fat cell differentiation; IEA:Compara.
 GO:0003151; P:outflow tract morphogenesis; IEA:Compara.
 GO:0032915; P:positive regulation of transforming growth factor beta2 production; IEA:Compara.
 GO:0006970; P:response to osmotic stress; ISS:UniProtKB. 

Interpro

 IPR004827; bZIP.
 IPR016378; TF_cAMP-dep.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF00170; bZIP_1 

SMART

 SM00338; BRLZ
 SM00355; ZnF_C2H2 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS