CPLM-014330

Genbank Nucleotide ID

B-cell receptor-associated protein 31

Protein Synonyms/Alias

BCR-associated protein 31; Bap31; p28

Mus musculus (Mouse)

Position	Peptide	Type	References
167	GAAEDGDKLDIGNTE	acetylation	[1]
167	GAAEDGDKLDIGNTE	ubiquitination	[2]
176	DIGNTEMKLEENKSL	ubiquitination	[2]
181	EMKLEENKSLKNDLR	ubiquitination	[2]
189	SLKNDLRKLKDELAS	acetylation	[1]
191	KNDLRKLKDELASTK	acetylation	[1, 3, 4, 5]
191	KNDLRKLKDELASTK	ubiquitination	[2]
203	STKKKLEKAENEALA	acetylation	[1]
203	STKKKLEKAENEALA	ubiquitination	[2]
213	NEALAMQKQSEGLTK	ubiquitination	[2]
231	RLLEEHAKLQASVRG	ubiquitination	[2]

[1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
[2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[3] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
[4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
[5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
J Biol Chem. 2013 Jul 17;. [PMID: 23864654]

Functional Description

May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity).

MOTIF 242 245 Di-lysine motif.

Apoptosis; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
GO:0000139; C:Golgi membrane; IDA:MGI.
GO:0005887; C:integral to plasma membrane; IEA:Compara.
GO:0005811; C:lipid particle; IEA:Compara.
GO:0005886; C:plasma membrane; IPI:MGI.
GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Compara.
GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara.
GO:0051561; P:elevation of mitochondrial calcium ion concentration; IEA:Compara.
GO:0006955; P:immune response; IPI:MGI.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Compara.
GO:0032471; P:reduction of endoplasmic reticulum calcium ion concentration; IEA:Compara.
GO:0007283; P:spermatogenesis; IEP:BHF-UCL.
GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.