CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001258
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Paralemmin-1 
Protein Synonyms/Alias
 Paralemmin 
Gene Name
 PALM 
Gene Synonyms/Alias
 KIAA0270 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
377DPQDLDMKKHRCKCCubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. 
Sequence Annotation
 MOD_RES 116 116 Phosphoserine.
 MOD_RES 124 124 Phosphoserine.
 MOD_RES 141 141 Phosphothreonine.
 MOD_RES 145 145 Phosphothreonine.
 MOD_RES 152 152 Phosphoserine (By similarity).
 MOD_RES 162 162 Phosphoserine.
 MOD_RES 346 346 Phosphoserine (By similarity).
 MOD_RES 367 367 Phosphothreonine (By similarity).
 MOD_RES 369 369 Phosphoserine (By similarity).
 MOD_RES 384 384 Cysteine methyl ester (Potential).
 LIPID 381 381 S-palmitoyl cysteine (Potential).
 LIPID 383 383 S-palmitoyl cysteine (Potential).
 LIPID 384 384 S-farnesyl cysteine (Potential).  
Keyword
 Alternative splicing; Cell membrane; Cell projection; Cell shape; Coiled coil; Complete proteome; Lipoprotein; Membrane; Methylation; Palmitate; Phosphoprotein; Polymorphism; Prenylation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 387 AA 
Protein Sequence
MEVLAAETTS QQERLQAIAE KRKRQAEIEN KRRQLEDERR QLQHLKSKAL RERWLLEGTP 60
SSASEGDEDL RRQMQDDEQK TRLLEDSVSR LEKEIEVLER GDSAPATAKE NAAAPSPVRA 120
PAPSPAKEER KTEVVMNSQQ TPVGTPKDKR VSNTPLRTVD GSPMMKAAMY SVEITVEKDK 180
VTGETRVLSS TTLLPRQPLP LGIKVYEDET KVVHAVDGTA ENGIHPLSSS EVDELIHKAD 240
EVTLSEAGST AGAAETRGAV EGAARTTPSR REITGVQAQP GEATSGPPGI QPGQEPPVTM 300
IFMGYQNVED EAETKKVLGL QDTITAELVV IEDAAEPKEP APPNGSAAEP PTEAASREEN 360
QAGPEATTSD PQDLDMKKHR CKCCSIM 387 
Gene Ontology
 GO:0016327; C:apicolateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030424; C:axon; IEA:UniProtKB-SubCell.
 GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; TAS:ProtInc.
 GO:0032590; C:dendrite membrane; IEA:Compara.
 GO:0032591; C:dendritic spine membrane; IEA:Compara.
 GO:0031527; C:filopodium membrane; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0006928; P:cellular component movement; TAS:ProtInc.
 GO:0071257; P:cellular response to electrical stimulus; IEA:Compara.
 GO:0007010; P:cytoskeleton organization; IEA:Compara.
 GO:0007194; P:negative regulation of adenylate cyclase activity; IDA:UniProtKB.
 GO:0060160; P:negative regulation of dopamine receptor signaling pathway; IDA:UniProtKB.
 GO:0060999; P:positive regulation of dendritic spine development; IEA:Compara.
 GO:0051491; P:positive regulation of filopodium assembly; IDA:UniProtKB.
 GO:0072661; P:protein targeting to plasma membrane; IEA:Compara.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
 GO:0060074; P:synapse maturation; IEA:Compara. 
Interpro
 IPR004965; Paralemmin. 
Pfam
 PF03285; Paralemmin 
SMART
  
PROSITE
  
PRINTS