UniProt Accession

 EPCAM_HUMAN; P16422; P18180; Q6FG26; Q6FG49; Q96C47; Q9UCD0 

Genbank Protein ID

 M32325; X14758; M26481; M32306; M33011; M93036; M93029; M93030; M93031; M93032; M93033; M93034; M93035; CR542259; CR542283; AC079775; CH471053; BC014785 

Genbank Nucleotide ID

 AAA36151.1; CAA32870.1; AAA59543.1; AAA35723.1; AAA35861.1; AAB00775.1; AAB00775.1; AAB00775.1; AAB00775.1; AAB00775.1; AAB00775.1; AAB00775.1; AAB00775.1; CAG47055.1; CAG47078.1; AAY15095.1; EAX00218.1; AAH14785.1 

Protein Name

 Epithelial cell adhesion molecule 

Protein Synonyms/Alias

 Ep-CAM; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; EGP; Epithelial glycoprotein 314; EGP314; hEGP314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; CD326 

Gene Name

 EPCAM 

Gene Synonyms/Alias

 GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
168	SLRTALQKEITTRYQ	ubiquitination	[1, 2]
218	DVAYYFEKDVKGESL	ubiquitination	[1]
291	VVLVISRKKRMAKYE	ubiquitination	[2]
299	KRMAKYEKAEIKEMG	ubiquitination	[1, 2]
303	KYEKAEIKEMGEMHR	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. 

Sequence Annotation

 DOMAIN 63 135 Thyroglobulin type-1.
 MOD_RES 24 24 Pyrrolidone carboxylic acid (Probable).
 CARBOHYD 74 74 N-linked (GlcNAc...); partial.
 CARBOHYD 111 111 N-linked (GlcNAc...).
 CARBOHYD 198 198 N-linked (GlcNAc...).
 DISULFID 27 46
 DISULFID 29 59
 DISULFID 38 48
 DISULFID 66 99
 DISULFID 110 116
 DISULFID 118 135  

Keyword

 Cell junction; Cell membrane; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hereditary nonpolyposis colorectal cancer; Membrane; Polymorphism; Pyrrolidone carboxylic acid; Reference proteome; Repeat; Signal; Tight junction; Transmembrane; Transmembrane helix; Tumor antigen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 314 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016328; C:lateral plasma membrane; IDA:UniProtKB.
 GO:0005923; C:tight junction; IDA:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
 GO:0001657; P:ureteric bud development; IEA:Compara. 

Interpro

 IPR000716; Thyroglobulin_1. 

Pfam

 PF00086; Thyroglobulin_1 

SMART

 SM00211; TY 

PROSITE

 PS00484; THYROGLOBULIN_1_1
 PS51162; THYROGLOBULIN_1_2 

PRINTS