UniProt Accession

 B2CL2_HUMAN; Q92843; A8K0F4; Q2M3U0; Q5U0H4 

Genbank Protein ID

 U59747; D87461; BT019549; AK289519; AL049829; CH471078; BC011637; BC021198; BC104789; BC113522 

Genbank Nucleotide ID

 AAB09055.1; BAA19666.2; AAV38356.1; BAF82208.1; EAW66169.1; AAH21198.1; AAI04790.1; AAI13523.1 

Protein Name

 Bcl-2-like protein 2 

Protein Synonyms/Alias

 Bcl2-L-2; Apoptosis regulator Bcl-W 

Gene Name

 BCL2L2 

Gene Synonyms/Alias

 BCLW; KIAA0271 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
162	EMEEEAEKLKELQNE	ubiquitination	[1]
164	EEEAEKLKELQNEVE	ubiquitination	[1, 2]
234	RVTILCDKFSGHPKG	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. 

Sequence Annotation

 MOTIF 9 29 BH4.
 MOTIF 85 104 BH1.
 MOTIF 136 151 BH2.
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Apoptosis; Complete proteome; Membrane; Mitochondrion; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
 GO:0060011; P:Sertoli cell proliferation; IEA:Compara.
 GO:0007283; P:spermatogenesis; TAS:ProtInc. 

Interpro

 IPR013280; Apop_reg_BclW.
 IPR002475; Bcl2-like.
 IPR020717; Bcl2_BH1_motif_CS.
 IPR020726; Bcl2_BH2_motif_CS.
 IPR003093; Bcl2_BH4.
 IPR020731; Bcl2_BH4_motif_CS.
 IPR026298; Blc2_fam. 

Pfam

 PF00452; Bcl-2
 PF02180; BH4 

SMART

 SM00265; BH4 

PROSITE

 PS50062; BCL2_FAMILY
 PS01080; BH1
 PS01258; BH2
 PS01260; BH4_1
 PS50063; BH4_2 

PRINTS

 PR01865; APOPREGBCLW.
 PR01862; BCL2FAMILY.