CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019528
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Testis-specific serine/threonine-protein kinase 3 
Protein Synonyms/Alias
 TSK-3; TSSK-3; Testis-specific kinase 3; Serine/threonine-protein kinase 22C 
Gene Name
 TSSK3 
Gene Synonyms/Alias
 SPOGA3; STK22C 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
112PLPESRAKALFRQMVacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May be involved in a signaling pathway during male germ cell development or mature sperm function. 
Sequence Annotation
 DOMAIN 10 265 Protein kinase.
 NP_BIND 16 24 ATP (By similarity).
 ACT_SITE 134 134 Proton acceptor (By similarity).
 BINDING 39 39 ATP (By similarity).  
Keyword
 ATP-binding; Complete proteome; Developmental protein; Differentiation; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Spermatogenesis; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 268 AA 
Protein Sequence
MEDFLLSNGY QLGKTIGEGT YSKVKEAFSK KHQRKVAIKV IDKMGGPEEF IQRFLPRELQ 60
IVRTLDHKNI IQVYEMLESA DGKICLVMEL AEGGDVFDCV LNGGPLPESR AKALFRQMVE 120
AIRYCHGCGV AHRDLKCENA LLQGFNLKLT DFGFAKVLPK SHRELSQTFC GSTAYAAPEV 180
LQGIPHDSKK GDVWSMGVVL YVMLCASLPF DDTDIPKMLW QQQKGVSFPT HLSISADCQD 240
LLKRLLEPDM ILRPSIEEVS WHPWLAST 268 
Gene Ontology
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
 GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0007283; P:spermatogenesis; ISS:UniProtKB. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS