CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018267
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone deacetylase 7 
Protein Synonyms/Alias
 HD7; Histone deacetylase 7A; HD7a 
Gene Name
 HDAC7 
Gene Synonyms/Alias
 HDAC7A 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
610CECLRGRKASLEELQubiquitination[1]
642RLKLDNGKLAGLLAQubiquitination[1, 2]
932AVIRVHSKYWGCMQRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. 
Sequence Annotation
 REGION 1 268 Transcription repression 1 (By
 REGION 1 98 Interaction with MEF2C (By similarity).
 REGION 49 149 Interaction with MEF2A (By similarity).
 REGION 218 546 Transcription repression 2 (By
 REGION 518 865 Histone deacetylase.
 REGION 877 952 Interaction with SIN3A (By similarity).
 MOTIF 918 952 Nuclear export signal (By similarity).
 ACT_SITE 670 670 By similarity.
 METAL 533 533 Zinc.
 METAL 535 535 Zinc.
 METAL 541 541 Zinc.
 METAL 618 618 Zinc.
 MOD_RES 109 109 Phosphoserine.
 MOD_RES 155 155 Phosphoserine; by MARK2, MARK3 and
 MOD_RES 181 181 Phosphoserine; by PKD/PRKD2.
 MOD_RES 283 283 Phosphoserine.
 MOD_RES 286 286 Phosphothreonine.
 MOD_RES 358 358 Phosphoserine; by PKD/PRKD1 (By
 MOD_RES 486 486 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Chromatin regulator; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 952 AA 
Protein Sequence
MHSPGADGTQ VSPGAHYCSP TGAGCPRPCA DTPGPQPQPM DLRVGQRPPV EPPPEPTLLA 60
LQRPQRLHHH LFLAGLQQQR SVEPMRLSMD TPMPELQVGP QEQELRQLLH KDKSKRSAVA 120
SSVVKQKLAE VILKKQQAAL ERTVHPNSPG IPYRTLEPLE TEGATRSMLS SFLPPVPSLP 180
SDPPEHFPLR KTVSEPNLKL RYKPKKSLER RKNPLLRKES APPSLRRRPA ETLGDSSPSS 240
SSTPASGCSS PNDSEHGPNP ILGSEALLGQ RLRLQETSVA PFALPTVSLL PAITLGLPAP 300
ARADSDRRTH PTLGPRGPIL GSPHTPLFLP HGLEPEAGGT LPSRLQPILL LDPSGSHAPL 360
LTVPGLGPLP FHFAQSLMTT ERLSGSGLHW PLSRTRSEPL PPSATAPPPP GPMQPRLEQL 420
KTHVQVIKRS AKPSEKPRLR QIPSAEDLET DGGGPGQVVD DGLEHRELGH GQPEARGPAP 480
LQQHPQVLLW EQQRLAGRLP RGSTGDTVLL PLAQGGHRPL SRAQSSPAAP ASLSAPEPAS 540
QARVLSSSET PARTLPFTTG LIYDSVMLKH QCSCGDNSRH PEHAGRIQSI WSRLQERGLR 600
SQCECLRGRK ASLEELQSVH SERHVLLYGT NPLSRLKLDN GKLAGLLAQR MFVMLPCGGV 660
GVDTDTIWNE LHSSNAARWA AGSVTDLAFK VASRELKNGF AVVRPPGHHA DHSTAMGFCF 720
FNSVAIACRQ LQQQSKASKI LIVDWDVHHG NGTQQTFYQD PSVLYISLHR HDDGNFFPGS 780
GAVDEVGAGS GEGFNVNVAW AGGLDPPMGD PEYLAAFRIV VMPIAREFSP DLVLVSAGFD 840
AAEGHPAPLG GYHVSAKCFG YMTQQLMNLA GGAVVLALEG GHDLTAICDA SEACVAALLG 900
NRVDPLSEEG WKQKPNLNAI RSLEAVIRVH SKYWGCMQRL ASCPDSWVPR VPGADKEEVE 960
AVTALASLSV GILAEDRPSE QLVEEEEPMN L 991 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0000118; C:histone deacetylase complex; IEA:InterPro.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0071889; F:14-3-3 protein binding; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.
 GO:0097372; F:NAD-dependent histone deacetylase activity (H3-K18 specific); IEA:EC.
 GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.
 GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0007043; P:cell-cell junction assembly; IEA:Compara.
 GO:0070932; P:histone H3 deacetylation; IEA:GOC.
 GO:0070933; P:histone H4 deacetylation; IEA:GOC.
 GO:0032703; P:negative regulation of interleukin-2 production; IDA:BHF-UCL.
 GO:0045668; P:negative regulation of osteoblast differentiation; IMP:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0007219; P:Notch signaling pathway; TAS:Reactome.
 GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IMP:BHF-UCL.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0001570; P:vasculogenesis; IEA:Compara. 
Interpro
 IPR000286; His_deacetylse.
 IPR023801; His_deacetylse_dom.
 IPR017320; Histone_deAcase_II_euk. 
Pfam
 PF00850; Hist_deacetyl 
SMART
  
PROSITE
  
PRINTS
 PR01270; HDASUPER.