CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027310
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription termination factor Rho 
Protein Synonyms/Alias
 ATP-dependent helicase Rho 
Gene Name
 rho 
Gene Synonyms/Alias
 LA_1021 
Created Date
 July 27, 2013 
Organism
 Leptospira interrogans serogroup Icterohaemorrhagiae serovar La 
NCBI Taxa ID
 189518 
Lysine Modification
Position
Peptide
Type
References
247VAPPRTGKTILMQNImethylation[1]
Reference
 [1] High-coverage proteome analysis reveals the first insight of protein modification systems in the pathogenic spirochete Leptospira interrogans.
 Cao XJ, Dai J, Xu H, Nie S, Chang X, Hu BY, Sheng QH, Wang LS, Ning ZB, Li YX, Guo XK, Zhao GP, Zeng R.
 Cell Res. 2010 Feb;20(2):197-210. [PMID: 19918266] 
Functional Description
 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity). 
Sequence Annotation
 NP_BIND 232 237 ATP (By similarity).
 NP_BIND 244 249 ATP (By similarity).
 BINDING 275 275 ATP (By similarity).  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome; RNA-binding; Transcription; Transcription regulation; Transcription termination. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 482 AA 
Protein Sequence
MATARRDNKN RHQHSNHNHN NQNDSGDSFE EESTNQESQE FDSSENSDPR SRKRKRGGYE 60
GPAPAPIDLV ELKKKAISDL IEVAKSLGVE NTGGLKKQNL IFAILQAQAE RDGQVHAAGV 120
MEKLPDGYGF LRSPDYNYVP GPDDIYVSPS QIKLFGLRTG DTVEGQIRPP KESERFFAML 180
RVETVNGYTP DVAGKRALFD NLTPLYPNER LKMEYDPSML DTRILDLMCP IGKGQRALIV 240
APPRTGKTIL MQNIANAITS NHPECSLIVL LIDERPEEVT DMARHVRGEV VSSTFDEPAQ 300
RHVQVAEMVI EKAKRLVEHG KDVVILLDSI TRLARAYNQV IPTSGKILSG GVDSNALHKP 360
KRFFGAARNI EEGGSLTIIA TALIDTGSKM DEVIFEEFKG TGNMEIHLDR KLSDKRIFPA 420
IDINKSGTRK EELLITKDVL QKVFVLRKVL SPMSITESME LLLEKMRLSK TNDAFLASMN 480
TQ 482 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0004386; F:helicase activity; IEA:HAMAP.
 GO:0003723; F:RNA binding; IEA:HAMAP.
 GO:0008186; F:RNA-dependent ATPase activity; IEA:InterPro.
 GO:0006353; P:DNA-dependent transcription, termination; IEA:HAMAP.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
 IPR011129; Cold_shock_prot.
 IPR012340; NA-bd_OB-fold.
 IPR027417; P-loop_NTPase.
 IPR011112; Rho_N.
 IPR011113; Rho_RNA-bd.
 IPR004665; Term_rho. 
Pfam
 PF00006; ATP-synt_ab
 PF07498; Rho_N
 PF07497; Rho_RNA_bind 
SMART
 SM00382; AAA
 SM00357; CSP
 SM00959; Rho_N 
PROSITE
  
PRINTS