| Tag | Content |
|---|
| CPLM ID | CPLM-024253 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pyruvate dehydrogenase E1 component |
Protein Synonyms/Alias | PDH E1 component |
Gene Name | aceE |
Gene Synonyms/Alias | MSMEG_4323; MSMEI_4223 |
Created Date | July 27, 2013 |
Organism | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) |
NCBI Taxa ID | 246196 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 375 | FGRDPRTKALVADMS | pupylation | [1] |
|
Reference | [1] Expansion of the mycobacterial "PUPylome". Watrous J, Burns K, Liu WT, Patel A, Hook V, Bafna V, Barry CE 3rd, Bark S, Dorrestein PC. Mol Biosyst. 2010 Feb;6(2):376-85. [ PMID: 20094657] |
Functional Description | Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). AceE has reductase activity with pyruvate but does not react with 2-oxoglutarate (By similarity). |
Sequence Annotation | CROSSLNK 375 375 Isoglutamyl lysine isopeptide (Lys-Gln) |
Keyword | Complete proteome; Glycolysis; Isopeptide bond; Magnesium; Oxidoreductase; Pyruvate; Reference proteome; Thiamine pyrophosphate; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 929 AA |
Protein Sequence | MTTEFVRQDL AQNSSTAAEP DRVRVIREGV ASYLPDIDTE ETAEWLESFD ELLERSGPAR 60
ARYLMLRLLE RAGEQRVAIP ALTSTDYVNT IPTELEPWFP GDEDVERRYR AWIRWNAAIM 120
VHRAQRPGVG VGGHISTYAS SATLYEVGFN HFFRGKSHPG GGDHVFIQGH ASPGIYARAF 180
LEGRLTTDQL DGFRQEHSHS GGGLPSYPHP RLMPDFWEFP TVSMGLGPMN AIYQARFNHY 240
LHDRGIKDTS DQHVWAFLGD GEMDEPESRG LIQVAANEAL DNLTFVINCN LQRLDGPVRG 300
NGKIIQELES FFRGAGWNVI KVVWGREWDV LLHADRDGAL VNLMNSTPDG DYQTYKANDG 360
AYVRDHFFGR DPRTKALVAD MSDQEIWNLK RGGHDYRKVY AAYRAAMEHK GQPTVILAKT 420
IKGYTLGQHF EGRNATHQMK KLALEDLKNF RDVTRVPVSD AQLEEDPYLP PYYHPGPEAP 480
EIRYLLERRR ALGGFVPSRR TKSKPLALPG SDTYKALKKG SGSQAVATTM ATVRTFKELL 540
RDKNIGPRIV PIIPDEARTF GMDSWFPSLK IYNRNGQLYT SVDSELMLAY KESEVGQILH 600
EGINEAGSTS SFTAVGTSYS THDEPMIPIY IFYSMFGFQR TGDGLWAAAD QMARGFVLGA 660
TAGRTTLTGE GLQHADGHSL LLASTNPAAV TYDPAFAYEI AHIIESGLQR MYGEDPENVF 720
FYLTIYNEPY QQPAEPENLD VEALLKGLYL YRPAPEKRAK SAQILASGVA MPEALRAADL 780
LASDWDVAAD VWSVTSWGEL NREGVAIEKH RLRHPDEPAG TPHVTSALAD AAGPVIAVSD 840
WMRAVPEQIR PWVPGTYVTL GTDGFGFSDT RPAARRYFNT DAESVVVAVL QGLARDGEID 900
ASVAAQAAEQ YRIDDVSAAG VSYADTGSA 929 |
Gene Ontology | GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:EC. GO:0006096; P:glycolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
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