Tag | Content |
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CPLM ID | CPLM-002698 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Galectin-3 |
Protein Synonyms/Alias | Gal-3; 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; IgE-binding protein; Laminin-binding protein; Lectin L-29; Mac-2 antigen |
Gene Name | Lgals3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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208 | AFPFESGKPFKIQVL | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells (By similarity). Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. |
Sequence Annotation | REPEAT 35 43 1. REPEAT 44 52 2. REPEAT 53 61 3. REPEAT 62 70 4. REPEAT 71 79 5. REPEAT 80 88 6. REPEAT 89 98 7; approximate. REPEAT 99 105 8; approximate. REPEAT 106 112 9; truncated. DOMAIN 130 260 Galectin. REGION 35 112 9 X 9 AA tandem repeats of Y-P-G-X(3)-P- REGION 193 199 Beta-galactoside binding (By similarity). MOTIF 238 253 Nuclear export signal (By similarity). MOD_RES 2 2 N-acetylalanine. MOD_RES 6 6 Phosphoserine; by CK1 (By similarity). DISULFID 185 185 Interchain (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Differentiation; Direct protein sequencing; Disulfide bond; IgE-binding protein; Immunity; Innate immunity; Lectin; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Secreted; Spliceosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 262 AA |
Protein Sequence | MADGFSLNDA LAGSGNPNPQ GWPGAWGNQP GAGGYPGASY PGAYPGQAPP GGYPGQAPPS 60 AYPGPTGPSA YPGPTAPGAY PGPTAPGAFP GQPGGPGAYP SAPGAYPSAP GAYPATGPFG 120 APTGPLTVPY DMPLPGGVMP RMLITIIGTV KPNANSITLN FKKGNDIAFH FNPRFNENNR 180 RVIVCNTKQD NNWGREERQS AFPFESGKPF KIQVLVEADH FKVAVNDVHL LQYNHRMKNL 240 REISQLGIIG DITLTSASHA MI 262 |
Gene Ontology | GO:0005743; C:mitochondrial inner membrane; IEA:Compara. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0005578; C:proteinaceous extracellular matrix; IEA:Compara. GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW. GO:0030246; F:carbohydrate binding; IEA:InterPro. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0030198; P:extracellular matrix organization; IEA:Compara. GO:0045087; P:innate immune response; IEA:UniProtKB-KW. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. GO:0001501; P:skeletal system development; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |