CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017200
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integrator complex subunit 9 
Protein Synonyms/Alias
 Int9 
Gene Name
 Ints9 
Gene Synonyms/Alias
 D14Ertd231e 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
58NLPGWSLKDGNAFLDubiquitination[1]
459LNFIQVSKLLKEVQPubiquitination[1]
582IPDCKVLKPLLSGSIacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 658 AA 
Protein Sequence
MKLYCLSGHP TLPCNVLKFK STTIMLDCGL DMTSTLNFLP LPLVQSPRLS NLPGWSLKDG 60
NAFLDKELKE CSGHVFVDSV PEFCLPETEL IDLSTVDVIL ISNYHCMMAL PYITEHTGFT 120
GTVYATEPTM QIGRLLMEEL VNFIERVPKA QSASLWKNKD IQRLLPSPLK DAVEVSTWRR 180
CYTMQEVNSA LSKIQLVGYS QKIELFGAVQ VTPLSSGYAL GSSNWIIQSH YEKVSYVSGS 240
SLLTTHPQPM DQASLKNSDV LILTGLTQIP TANPDGMVGE FCSNLALTVR NGGNVLVPCY 300
PSGVIYDLLE CLYQYIDSAG LSNIPFYFIS PVANSSLEFS QIFAEWLCHN KQSKVYLPEP 360
PFPHAELIQT NKLKHYRSIH GDFSNDFRQP CVLFTGHPSL RFGDVVHFME LWGKSSLNTI 420
IFTEPDFSYL EALAPYQPLA MKCIYCPIDT RLNFIQVSKL LKEVQPLHVV CPEQYTQPPP 480
AQAHRMDLMI DCQPPAMSYR RAEVLALPFK RRYEKIEIMP ELADSLVPME IKPGISLATV 540
SAVLHTKDNK HVLQPPPKPT QPTSSKKRKR VNEDIPDCKV LKPLLSGSIP VEQFVQTLEK 600
HGFSDIKVED TAKGHIVLLQ EAETLIQIEE DSTHIICDND ETLRVRLRDL VLRFLQKF 658 
Gene Ontology
 GO:0032039; C:integrator complex; IEA:Compara.
 GO:0016787; F:hydrolase activity; IEA:InterPro.
 GO:0016180; P:snRNA processing; IEA:Compara. 
Interpro
 IPR001279; Beta-lactamas-like.
 IPR022712; Beta_Casp.
 IPR027074; Integrator_9su. 
Pfam
 PF10996; Beta-Casp 
SMART
 SM01027; Beta-Casp 
PROSITE
  
PRINTS