Tag | Content |
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CPLM ID | CPLM-024607 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | BAG family molecular chaperone regulator 1 |
Protein Synonyms/Alias | BAG-1; Bcl-2-associated athanogene 1 |
Gene Name | Bag1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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255 | DLEVSVEKTANHLEE | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli (By similarity). |
Sequence Annotation | REPEAT 102 111 1. REPEAT 114 119 2. REPEAT 120 125 3. REPEAT 126 131 4. REPEAT 132 137 5. REPEAT 144 149 6. REPEAT 150 155 7. DOMAIN 157 237 Ubiquitin-like. DOMAIN 259 339 BAG. REGION 114 212 7 X 6 AA tandem repeat of E-E-X(4). REGION 185 232 Interaction with HSPA8 (By similarity). REGION 229 358 Interaction with PPP1R15A (By |
Keyword | Apoptosis; Chaperone; Complete proteome; Cytoplasm; Nucleus; Reference proteome; Repeat; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 358 AA |
Protein Sequence | MADRGGARRP RGDQEPLGPR LRAPRSARET RQSESRAERG LPPSQRSSVR SAASGHDRST 60 RGAASGACKP RVKKKVRPRS SQSEKVAHSK ELTRSKKLTR SKKVTGTQEA TQVEEVTTIE 120 EATQTEEITV AEEVTQTENM AQTEEMVQTE EMEPPTLSVV VTHSNERYDL LVTPQQGNSE 180 PIVQDLAQLV EEATGVPLPF QKLIFKGKSL KEMETPLSAL GMQNGCRVML IGEKSNPEEE 240 AELKKLKDLE VSVEKTANHL EELNKELSDI QQGFLAKELQ AEALCRLDRK IKATIEQFMK 300 ILEEIDTMVL PENFKDSRLK RKNLVKKVQV FLAECDTVEQ YICQETERLQ STNLALPE 358 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |