CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040867
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sushi domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 SUSD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
284ITSVCTEKGTWRESTubiquitination[1]
686EYYNAPLKRGSDYCIubiquitination[2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; EGF-like domain; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 722 AA 
Protein Sequence
MGRGPWDAGP SRRLLPLLLL LGLARGAAGA PGPDGLDVCA TCHEHATCQQ REGKKICICN 60
YGFVGNGRTQ CVDKNECQFG ATLVCGNHTS CHNTPGGFYC ICLEGYRATN NNKTFIPNDG 120
TFCTDIDECE VSGLCRHGGR CVNTHGSFEC YCMDGYLPRN GPEPFHPTTD ATSCTEIDCG 180
TPPEVPDGYI IGNYTSSLGS QVRYACREGF FSVPEDTVSS CTGLGTWESP KLHCQEINCG 240
NPPEMRHAIL VGNHSSRLGG VARYVCQEGF ESPGGKITSV CTEKGTWRES TLTCTEILTK 300
INDVSLFNDT CVRWQINSRR INPKISYVIS IKGQRLDPME SVREETVNLT TDSRTPEVCL 360
ALYPGTNYTV NISTAPPRRS MPAVIGFQTA EVDLLEDDGS FNISIFNETC LKLNRRSRKV 420
GSEHMYQFTV LGQRWYLANF SHATSFNFTT REQVPVVCLD LYPTTDYTVN VTLLRSPKRH 480
SVQITIATPP AVKQTISNIS GFNETCLRWR SIKTADMEEM YLFHIWGQRW YQKEFAQEMT 540
FNISSSSRDP EVCLDLRPGT NYNVSLRALS SELPVVISLT TQITEPPLPE VEFFTVHRGP 600
LPRLRLRKAK EKNGPISSYQ VLVLPLALQS TFSCDSEGAS SFFSNASDAD GYVAAELLAK 660
DVPDDAMEIP IGDRLYYGEY YNAPLKRGSD YCIILRITSE WNKIRHSCCC RWRVLDWVPW 720
LL 722 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro. 
Interpro
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR023413; GFP_like.
 IPR000436; Sushi_SCR_CCP. 
Pfam
 PF07645; EGF_CA
 PF00084; Sushi 
SMART
 SM00032; CCP
 SM00181; EGF
 SM00179; EGF_CA 
PROSITE
 PS00010; ASX_HYDROXYL
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS50923; SUSHI 
PRINTS