CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022978
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Translation initiation factor eIF-2B subunit delta 
Protein Synonyms/Alias
 eIF-2B GDP-GTP exchange factor subunit delta 
Gene Name
 EIF2B4 
Gene Synonyms/Alias
 EIF2BD 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
486DPDDLQCKRGEHVALubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. 
Sequence Annotation
 MOD_RES 86 86 Phosphothreonine.  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Initiation factor; Leukodystrophy; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 523 AA 
Protein Sequence
MPTQQPAAPS TRAPKPSRSL SGSLCALFSD ADSGSGMKAE LPPGPGAVGR EMTKEEKLQL 60
RKEKKQQKKK RKEEKGAEPE TGSAVSAAQC QGPTRELPES GIQLGTPREK VPAGRSKAEL 120
RAERRAKQEA ERALKQARKG EQGGPPPKAS PSTAGETPSG VKRLPEYPQV DDLLLRRLVK 180
KPERQQVPTR KDYGSKVSLF SHLPQYSRQN SLTQFMSIPS SVIHPAMVRL GLQYSQGLVS 240
GSNARCIALL RALQQVIQDY TTPPNEELSR DLVNKLKPYM SFLTQCRPLS ASMHNAIKFL 300
NKEITSVGSS KREEEAKSEL RAAIDRYVQE KIVLAAQAIS RFAYQKISNG DVILVYGCSS 360
LVSRILQEAW TEGRRFRVVV VDSRPWLEGR HTLRSLVHAG VPASYLLIPA ASYVLPEVSK 420
VLLGAHALLA NGSVMSRVGT AQLALVARAH NVPVLVCCET YKFCERVQTD AFVSNELDDP 480
DDLQCKRGEH VALANWQNHA SLRLLNLVYD VTPPELVDLV ITELGMIPCS SVPVVLRVKS 540
SDQ 543 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005851; C:eukaryotic translation initiation factor 2B complex; IDA:UniProtKB.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0031369; F:translation initiation factor binding; ISS:UniProtKB.
 GO:0042552; P:myelination; IMP:UniProtKB.
 GO:0032057; P:negative regulation of translational initiation in response to stress; ISS:UniProtKB.
 GO:0014003; P:oligodendrocyte development; IMP:UniProtKB.
 GO:0001541; P:ovarian follicle development; IMP:UniProtKB.
 GO:0009749; P:response to glucose stimulus; ISS:UniProtKB.
 GO:0009408; P:response to heat; ISS:UniProtKB.
 GO:0043434; P:response to peptide hormone stimulus; ISS:UniProtKB.
 GO:0006413; P:translational initiation; IDA:UniProtKB. 
Interpro
 IPR000649; IF-2B-related. 
Pfam
 PF01008; IF-2B 
SMART
  
PROSITE
  
PRINTS