CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007625
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Excitatory amino acid transporter 2 
Protein Synonyms/Alias
 Glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 
Gene Name
 SLC1A2 
Gene Synonyms/Alias
 EAAT2; GLT1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
571SVEEEPWKREK****sumoylation[1]
Reference
 [1] A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis.
 Gibb SL, Boston-Howes W, Lavina ZS, Gustincich S, Brown RH Jr, Pasinelli P, Trotti D.
 J Biol Chem. 2007 Nov 2;282(44):32480-90. [PMID: 17823119] 
Functional Description
 Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. 
Sequence Annotation
 MOD_RES 494 494 Phosphotyrosine (By similarity).
 MOD_RES 539 539 Phosphotyrosine (By similarity).
 MOD_RES 564 564 Phosphoserine (By similarity).
 LIPID 38 38 S-palmitoyl cysteine (By similarity).
 CARBOHYD 206 206 N-linked (GlcNAc...) (Potential).
 CARBOHYD 216 216 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 574 AA 
Protein Sequence
MASTEGANNM PKQVEVRMHD SHLGSEEPKH RHLGLRLCDK LGKNLLLTLT VFGVILGAVC 60
GGLLRLASPI HPDVVMLIAF PGDILMRMLK MLILPLIISS LITGLSGLDA KASGRLGTRA 120
MVYYMSTTII AAVLGVILVL AIHPGNPKLK KQLGPGKKND EVSSLDAFLD LIRNLFPENL 180
VQACFQQIQT VTKKVLVAPP PDEEANATSA VVSLLNETVT EVPEETKMVI KKGLEFKDGM 240
NVLGLIGFFI AFGIAMGKMG DQAKLMVDFF NILNEIVMKL VIMIMWYSPL GIACLICGKI 300
IAIKDLEVVA RQLGMYMVTV IIGLIIHGGI FLPLIYFVVT RKNPFSFFAG IFQAWITALG 360
TASSAGTLPV TFRCLEENLG IDKRVTRFVL PVGATINMDG TALYEAVAAI FIAQMNGVVL 420
DGGQIVTVSL TATLASVGAA SIPSAGLVTM LLILTAVGLP TEDISLLVAV DWLLDRMRTS 480
VNVVGDSFGA GIVYHLSKSE LDTIDSQHRV HEDIEMTKTQ SIYDDMKNHR ESNSNQCVYA 540
AHNSVIVDEC KVTLAANGKS ADCSVEEEPW KREK 574 
Gene Ontology
 GO:0030673; C:axolemma; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0015501; F:glutamate:sodium symporter activity; IEA:Compara.
 GO:0005313; F:L-glutamate transmembrane transporter activity; TAS:ProtInc.
 GO:0017153; F:sodium:dicarboxylate symporter activity; IEA:InterPro.
 GO:0030534; P:adult behavior; IEA:Compara.
 GO:0031668; P:cellular response to extracellular stimulus; IEA:Compara.
 GO:0070779; P:D-aspartate import; IDA:UniProtKB.
 GO:0051938; P:L-glutamate import; IDA:UniProtKB.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0010259; P:multicellular organismal aging; IEA:Compara.
 GO:0046326; P:positive regulation of glucose import; IEA:Compara.
 GO:0043200; P:response to amino acid stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0009611; P:response to wounding; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:ProtInc.
 GO:0021537; P:telencephalon development; IEA:Compara.
 GO:0007632; P:visual behavior; IEA:Compara. 
Interpro
 IPR001991; Na-dicarboxylate_symporter.
 IPR018107; Na-dicarboxylate_symporter_CS. 
Pfam
 PF00375; SDF 
SMART
  
PROSITE
 PS00713; NA_DICARBOXYL_SYMP_1
 PS00714; NA_DICARBOXYL_SYMP_2 
PRINTS
 PR00173; EDTRNSPORT.