| Tag | Content |
|---|
| CPLM ID | CPLM-014468 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Arginine-glutamic acid dipeptide repeats protein |
Protein Synonyms/Alias | Atrophin-1-related protein |
Gene Name | Rere |
Gene Synonyms/Alias | Arp |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 556 | DPPPFMFKPVKEEDD | acetylation | [1] | | 920 | PLAMPHIKPPPTTPI | acetylation | [1] | | 1150 | FMPLAGSKLAKKREE | acetylation | [1] | | 1317 | RELRERMKPGFEVKP | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival (By similarity). Interacts with FAT1 (By similarity). |
Sequence Annotation | DOMAIN 102 282 BAH.
DOMAIN 283 386 ELM2.
DOMAIN 390 442 SANT.
ZN_FING 507 532 GATA-type.
MOD_RES 53 53 Phosphoserine (By similarity).
MOD_RES 56 56 Phosphoserine (By similarity).
MOD_RES 303 303 Phosphoserine (By similarity).
MOD_RES 599 599 Phosphoserine (By similarity).
MOD_RES 641 641 Phosphoserine (By similarity).
MOD_RES 655 655 Phosphoserine (By similarity).
MOD_RES 674 674 Phosphoserine (By similarity).
MOD_RES 678 678 Phosphoserine (By similarity).
MOD_RES 1098 1098 Phosphoserine (By similarity). |
Keyword | Coiled coil; Complete proteome; Developmental protein; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1559 AA |
Protein Sequence | MTADKDKDKD KEKDRDRDRD RERDKRDKAR ESENARPRRS CTLEGGAKNY AESDHSEDED 60
NDNGATTEES ARKSRKKPPK KKSRYERTDT GEITSYITED DVVYRPGDCV YIESRRPNTP 120
YFICSIQDFK LVHNSQACCR SPAPALCDPP ACSLPVASQP PQHLSEAGRG PVGSKRDHLL 180
MNVKWYYRQS EVPDSVYQHL VQDRHNENDS GRELVITDPV IKNRELFISD YVDTYHAAAL 240
RGKCNISHFS DIFAAREFKA RVDSFFYILG YNPETRRLNS TQGEIRVGPS HQAKLPDLQP 300
FPSPDGDTVT QHEELVWMPG VSDCDLLMYL RAARSMAAFA GMCDGGSTED GCVAASRDDT 360
TLNALNTLHE SSYDAGKALQ RLVKKPVPKL IEKCWTEDEV KRFVKGLRQY GKNFFRIRKE 420
LLPNKETGEL ITFYYYWKKT PEAASSRAHR RHRRQAVFRR IKTRTASTPV NTPSRPPSSE 480
FLDLSSASED DFDSEDSEQE LKGYACRHCF TTTSKDWHHG GRENILLCTD CRIHFKKYGE 540
LPPIEKPVDP PPFMFKPVKE EDDGLSGKHS MRTRRSRGSM STLRSGRKKQ PASPDGRASP 600
VNEDVRSSGR NSPSAASTSS NDSKAEAVKK SAKKVKEEAA SPLKNTKRQR EKVASDTEDT 660
DRATSKKTKT QEISRPNSPS EGEGESSDSR SVNDEGSSDP KDIDQDNRST SPSIPSPQDN 720
ESDSDSSAQQ QMLQTQPPAL QAPSGAASAP STAPPGTTQL PTPGPTPSAT TVPPQGSPAT 780
SQPPNQTQST VAPAAHTLIQ QTPTLHPPRL PSPHPPLQPM TAPPSQNSAQ PHPQPSLHGQ 840
GPPGPHSLQT GPLLQHPGPP QPFGLTPQSS QGQGPLGPSP AAAHPHSTIQ LPASQSALQP 900
QQPPREQPLP PAPLAMPHIK PPPTTPIPQL PAPQAHKHPP HLSGPSPFSM NANLPPPPAL 960
KPLSSLSTHH PPSAHPPPLQ LMPQSQPLPS SPAQPPGLTQ SQSLPPPAAS HPTTGGLHQV 1020
PSQSPFPQHP FVPGGPPPIT PPSCPPTSTP PAGPSSSSQP PCSAAVSSGG NVPGAPSCPL 1080
PAVQIKEEAL DEAEEPESPP PPPRSPSPEP TVVDTPSHAS QSARFYKHLD RGYNSCARTD 1140
LYFMPLAGSK LAKKREEAIE KAKREAEQKA REEREREKEK EKERERERER EREAERAAQK 1200
ASSSAHEGRL SDPQLSGPGH MRPSFEPPPT TIAAVPPYIG PDTPALRTLS EYARPHVMSP 1260
TNRNHPFYMP LNPTDPLLAY HMPGLYNVDP TIRERELRER EIREREIRER ELRERMKPGF 1320
EVKPPELDPL HPATNPMEHF ARHSALTIPP AAGPHPFASF HPGLNPLERE RLALAGPQLR 1380
PEMSYPDRLA AERIHAERMA SLTSDPLARL QMFNVTPHHH QHSHIHSHLH LHQQDPLHQG 1440
SAGPVHPLVD PLTAGPHLAR FPYPPGTLPN PLLGQPPHEH EMLRHPVFGT PYPRDLPGAI 1500
PPPMSAAHQL QAMHAQSAEL QRLAMEQQWL HGHPHMHGGH LPSQEDYYSR LKKEGDKQL 1559 |
Gene Ontology | GO:0000118; C:histone deacetylase complex; IEA:Compara. GO:0005739; C:mitochondrion; IEA:Compara. GO:0016605; C:PML body; IEA:UniProtKB-SubCell. GO:0003682; F:chromatin binding; IEA:InterPro. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006338; P:chromatin remodeling; IEA:Compara. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |