UniProt Accession

 C1GLT_HUMAN; Q9NS00; Q96QH4; Q9BTU1 

Genbank Protein ID

 AF155582; AJ132443; AJ278960; AJ243256; AC005532; CH236948; BC003174 

Genbank Nucleotide ID

 AAF81981.1; CAC45046.1; CAC82373.1; CAC80435.1; AAQ96887.1; EAL24308.1; AAH03174.1 

Protein Name

 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 

Protein Synonyms/Alias

 B3Gal-T8; Core 1 O-glycan T-synthase; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; Beta-1,3-galactosyltransferase; Core 1 beta1,3-galactosyltransferase 1; C1GalT1; Core 1 beta3-Gal-T1 

Gene Name

 C1GALT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
127	FMSSEENKDFPAVGL	ubiquitination	[1]
146	GRDQLYWKTIKAFQY	ubiquitination	[1]
185	NLRWLLSKYDPEEPI	ubiquitination	[1, 2]
228	KRFVDAFKTDKCTHS	ubiquitination	[1]
345	TLPERILKEISQANK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development. 

Sequence Annotation

 MOD_RES 235 235 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Angiogenesis; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycosyltransferase; Magnesium; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 363 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IDA:UniProtKB.
 GO:0016263; F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0001525; P:angiogenesis; IMP:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0001822; P:kidney development; IMP:UniProtKB.
 GO:0016266; P:O-glycan processing; TAS:Reactome.
 GO:0043687; P:post-translational protein modification; TAS:Reactome. 

Interpro

 IPR026842; C1GALT1.
 IPR003378; Fringe-like. 

Pfam

 PF02434; Fringe 

SMART

  

PROSITE

  

PRINTS