UniProt Accession

 PTF1A_HUMAN; Q7RTS3; Q9HC25 

Genbank Protein ID

 AL139281; AF181999; BK000272 

Genbank Nucleotide ID

 CAI12668.1; AAG09441.1; DAA01052.1 

Protein Name

 Pancreas transcription factor 1 subunit alpha 

Protein Synonyms/Alias

 Class A basic helix-loop-helix protein 29; bHLHa29; Pancreas-specific transcription factor 1a; bHLH transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1; PTF1-p48 

Gene Name

 PTF1A 

Gene Synonyms/Alias

 BHLHA29; PTF1P48 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
201	PYEKRLSKVDTLRLA	acetylation	[1]
201	PYEKRLSKVDTLRLA	ubiquitination	[2]

Reference

 [1] p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation.
 Rodolosse A, Campos ML, Rooman I, Lichtenstein M, Real FX.
 Biochem J. 2009 Mar 1;418(2):463-73. [PMID: 18834332]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Transcriptional activator. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays an important role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells (By similarity). Plays an important role in cerebellar development. 

Sequence Annotation

 DOMAIN 163 215 bHLH.  

Keyword

 Complete proteome; Cytoplasm; Developmental protein; Diabetes mellitus; Differentiation; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 328 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005667; C:transcription factor complex; ISS:UniProtKB.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0009790; P:embryo development; IEA:Compara.
 GO:0031018; P:endocrine pancreas development; TAS:Reactome.
 GO:0031017; P:exocrine pancreas development; ISS:UniProtKB.
 GO:0030902; P:hindbrain development; IEA:Compara.
 GO:0048663; P:neuron fate commitment; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0060042; P:retina morphogenesis in camera-type eye; IEA:Compara.
 GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Compara.
 GO:0009888; P:tissue development; IDA:UniProtKB. 

Interpro

 IPR011598; bHLH_dom. 

Pfam

 PF00010; HLH 

SMART

 SM00353; HLH 

PROSITE

 PS50888; BHLH 

PRINTS