CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043270
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tuberin 
Protein Synonyms/Alias
  
Gene Name
 TSC2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18TMAKPTSKDSGLKEKubiquitination[1]
25KDSGLKEKFKILLGLubiquitination[1]
27SGLKEKFKILLGLGTubiquitination[1]
45NPRSAEGKQTEFIITubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1751 AA 
Protein Sequence
MEGFSGASWS TMAKPTSKDS GLKEKFKILL GLGTPRPNPR SAEGKQTEFI ITAEILRELS 60
MECGLNNRIR MIGQICEVAK TKKFEEHAVE ALWKAVADLL QPERPLEARH AVLALLKAIV 120
QGQGERLGVL RALFFKVIKD YPSNEDLHER LEVFKALTDN GRHITYLEEE LADFVLQWMD 180
VGLSSEFLLV LVNLVKFNSC YLDEYIARMV QMICLLCVRT ASSVDIEVSL QVLDAVVCYN 240
CLPAESLPLF IVTLCRTINV KELCEPCWKL MRNLLGTHLG HSAIYNMCHL MEDRAYMEDA 300
PLLRGAVFFV GMALWGAHRL YSLRNSPTSV LPSFYQAMAC PNEVVSYEIV LSITRLIKKY 360
RKELQVVAWD ILLNIIERLL QQLQTLDSPE LRTIVHDLLT TVEELCDQNE FHGSQERYFE 420
LVERCADQRP ESSLLNLISY RAQSIHPAKD GWIQNLQALM ERFFRSESRG AVRIKVLDVL 480
SFVLLINRQF YEEELINSVV ISQLSHIPED KDHQVRKLAT QLLVDLAEGC HTHHFNSLLD 540
IIEKVMARSL SPPPELEERD VAAYSASLED VKTAVLGLLV ILQTKLYTLP ASHATRVYEM 600
LVSHIQLHYK HSYTLPIASS IRLQAFDFLL LLRADSLHRL GLPNKDGVVR FSPYCVCDYM 660
EPERGSEKKT SGPLSPPTGP PGPAPAGPAV RLGSVPYSLL FRVLLQCLKQ ESDWKVLKLV 720
LGRLPESLRY KVLIFTSPCS VDQLCSALCS MLSGPKTLER LRGAPEGFSR TDLHLAVVPV 780
LTALISYHNY LDKTKQREMV YCLEQGLIHR CASQCVVALS ICSVEMPDII IKALPVLVVK 840
LTHISATASM AVPLLEFLST LARLPHLYRN FAAEQYASVF AISLPYTNPS KFNQYIVCLA 900
HHVIAMWFIR CRLPFRKDFV PFITKGLRSN VLLSFDDTPE KDSFRARSTS LNERPKRIQT 960
SLTSASLGSA DENSVAQADD SLKNLHLELT ETCLDMMARY VFSNFTAVPK RSPVGEFLLA 1020
GGRTKTWLVG NKLVTVTTSV GTGTRSLLGL DSGELQSGPE SSSSPGVHVR QTKEAPAKLE 1080
SQAGQQVSRG ARDRVRSMSG GHGLRVGALD VPASQFLGSA TSPGPRTAPA AKPEKASAGT 1140
RVPVQEKTNL AAYVPLLTQG WAEILVRRPT GNTSWLMSLE NPLSPFSSDI NNMPLQELSN 1200
ALMAAERFKE HRDTALYKSL SVPAASTAKP PPLPRSNTDS AVVMEEGSPG EVPVLVEPPG 1260
LEDVEAALGM DRRTDAYSRS SSVSSQEEKS LHAEELVGRG IPIERVVSSE GGRPSVDLSF 1320
QPSQPLSKSS SSPELQTLQD ILGDPGDKAD VGRLSPEVKA RSQSGTLDGE SAAWSASGED 1380
SRGQPEGPLP SSSPRSPSGL RPRGYTISDS APSRRGKRVE RDALKSRATA SNAEKVPGIN 1440
PSFVFLQLYH SPFFGDESNK PILLPNESQS FERSVQLLDQ IPSYDTHKIA VLYVGEGQSN 1500
SELAILSNEH GSYRYTEFLT GLGRLIELKD CQPDKVYLGG LDVCGEDGQF TYCWHDDIMQ 1560
AVFHIATLMP TKDVDKHRCD KKRHLGNDFV SIVYNDSGED FKLGTIKGQF NFVHVIVTPL 1620
DYECNLVSLQ CRKDMEGLVD TSVAKIVSDR NLPFVARQMA LHANMASQVH HSRSNPTDIY 1680
PSKWIARLRH IKRLRQRICE EAAYSNPSLP LVHPPSHSKA PAQTPAEPTP GYEVGQRKRL 1740
ISSVEDFTEF V 1751 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
 GO:0005096; F:GTPase activator activity; IEA:InterPro.
 GO:0032007; P:negative regulation of TOR signaling cascade; IEA:InterPro.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000331; Rap_GAP_dom.
 IPR003913; Tuberin.
 IPR018515; Tuberin-type_domain.
 IPR027107; Tuberin/Ral-act_asu.
 IPR024584; Tuberin_N. 
Pfam
 PF11864; DUF3384
 PF02145; Rap_GAP
 PF03542; Tuberin 
SMART
  
PROSITE
 PS50085; RAPGAP 
PRINTS
 PR01431; TUBERIN.