CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039760
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein unc-13 homolog C 
Protein Synonyms/Alias
  
Gene Name
 UNC13C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1496SLRIDLSKYRENFPAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2214 AA 
Protein Sequence
MVANFFKSLI LPYIHKLCKG MFTKKLGNTN KNKEYRQQKK DQDFPTAGQT KSPKFSYTFK 60
STVKKIAKCS STHNLSTEED EASKEFSLSP TFSYRVAIAN GLQKNAKVTN SDNEDLLQEL 120
SSIESSYSES LNELRSSTEN QAQSTHTMPV RRNRKSSSSL APSEGSSDGE RTLHGLKLGA 180
LRKLRKWKKS QECVSSDSEL STMKKSWGIR SKSLDRTVRN PKTNALEPGF SSSGCISQTH 240
DVMEMIFKEL QGISQIETEL SELRGHVNAL KHSIDEISSS VEVVQSEIEQ LRTGFVQSRR 300
ETRDIHDYIK HLGHMGSKAS LRFLNVTEER FEYVESVVYQ ILIDKMGFSD APNAIKIEFA 360
QRIGHQRDCP NAKPRPILVY FETPQQRDSV LKKSYKLKGT GIGISTDILT HDIRERKEKG 420
IPSSQTYESM AIKLSTPEPK IKKNNWQSPD DSDEDLESDL NRNSYAVLSK SELLTKGSTS 480
KPSSKSHSAR SKNKTANSSR ISNKSDYDKI SSQLPESDIL EKQTTTHYAD ATPLWHSQSD 540
FFTAKLSRSE SDFSKLCQSY SEDFSENQFF TRTNGSSLLS SSDRELWQRK QEGTATLYDS 600
PKDQHLNGGV QGIQGQTETE NTETVDSGMS NGMVCASGDR SHYSDSQLSL HEDLSPWKEW 660
NQGADLGLDS STQEGFDYET NSLFDQQLDV YNKDLEYLGK CHSDLQDDSE SYDLTQDDNS 720
SPCPGLDNEP QGQWVGQYDS YQGANSNELY QNQNQLSMMY RSQSELQSDD SEDAPPKSWH 780
SRLSIDLSDK TFSFPKFGST LQRAKSALEV VWNKSTQSLS GYEDSGSSLM GRFRTLSQST 840
ANESSTTLDS DVYTEPYYYK AEDEEDYTEP VADNETDYVE VMEQVLAKLE NRTSITETDE 900
QMQAYDHLSY ETPYETPQDE GYDGPADDMV SEEGLEPLNE TSAEMEIRED ENQNIPEQPV 960
EITKPKRIRP SFKEAALRAY KKQMAELEEK ILAGVSLDVD LEARIVSGND LDASKFSALQ 1020
VCGGAGGGLY GIDSMPDLRR KKTLPIVRDV LLTLAARKSG LSLAMVIRTS LNNEELKMHV 1080
FKKTLQALIY PMSSTIPHNF EVWTATTPTY CYECEGLLWG IARQGMKCLE CGVKCHEKCQ 1140
DLLNADCLQR AAEKSSKHGA EDKTQTIITA MKERMKIREK NRPEVFEVIQ EMFQISKEDF 1200
VQFTKAAKQS VLDGTSKWSA KITITVVSAQ GLQAKDKTGS SDPYVTVQVG KNKRRTKTIF 1260
GNLNPVWDEK FYFECHNSTD RIKVRVWDED DDIKSRVKQH FKKESDDFLG QTIVEVRTLS 1320
GEMDVWYNLE KRTDKSAVSG AIRLKINVEI KGEEKVAPYH IQYTCLHENL FHYLTEVKSN 1380
GGVKIPEVKG DEAWKVFFDD ASQEIVDEFA MRYGIESIYQ AMTHFSCLSS KYMCPGVPAV 1440
MSTLLANINA FYAHTTVSTN IQVSASDRFA ATNFGREKFI KLLDQLHNSL RIDLSKYREN 1500
FPASNTERLQ DLKSTVDLLT SITFFRMKVL ELQSPPKASM VVKDCVRACL DSTYKYIFDN 1560
CHELYSQLTD PSKKQDIPRE DQGPTTKNLD FWPQLITLMV TIIDEDKTAY TPVLNQFPQE 1620
LNMGKISAEI MWTLFALDMK YALEEHENQR LCKSTDYMNL HFKVKWFYNE YVRELPAFKD 1680
AVPEYSLWFE PFVMQWLDEN EDVSMEFLHG ALGRDKKDGF QQTSEHALFS CSVVDVFAQL 1740
NQSFEIIKKL ECPNPEALSH LMRRFAKTIN KVLLQYAAIV SSDFSSHCDK ENVPCILMNN 1800
IQQLRVQLEK MFESMGGKEL DSEASTILKE LQVKLSGVLD ELSVTYGESF QVIIEECIKQ 1860
MSFELNQMRA NGNTTSNKNS AAMDAEIVLR SLMDFLDKTL SLSAKICEKT VLKRVLKELW 1920
KLVLNKIEKQ IVLPPLTDQT GPQMIFIAAK DLGQLSKLKE HMIREDARGL TPRQCAIMEV 1980
VLATIKQYFH AGGNGLKKNF LEKSPDLQSL RYALSLYTQT TDALIKKFID TQTSQSRSSK 2040
DAVGQISVHV DITATPGTGD HKVTVKVIAI NDLNWQTTAM FRPFVEVCIL GPNLGDKKRK 2100
QGTKTKSNTW SPKYNETFQF ILGKENRPGA YELHLSVKDY CFAREDRIIG MTVIQLQNIA 2160
EKGSYGAWYP LLKNISMDET GLTILRILSQ RTSDDVAKEF VRLKSETRST EESA 2214 
Gene Ontology
 GO:0019992; F:diacylglycerol binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0007268; P:synaptic transmission; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR020477; C2_dom.
 IPR018029; C2_membr_targeting.
 IPR010439; Ca-dep_secretion_activator.
 IPR014770; Munc13_1.
 IPR014772; Munc13_dom-2.
 IPR019558; Munc13_subgr_dom-2.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR027080; Unc-13.
 IPR027087; Unc13C. 
Pfam
 PF00130; C1_1
 PF00168; C2
 PF06292; DUF1041
 PF10540; Membr_traf_MHD 
SMART
 SM00109; C1
 SM00239; C2 
PROSITE
 PS50004; C2
 PS51258; MHD1
 PS51259; MHD2
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS
 PR00360; C2DOMAIN.