CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018859
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Canalicular multispecific organic anion transporter 1 
Protein Synonyms/Alias
 ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2 
Gene Name
 ABCC2 
Gene Synonyms/Alias
 CMOAT; CMOAT1; CMRP; MRP2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
63TKRSSTTKLYLAKQVubiquitination[1]
278ARLPGLNKNQSQSQDubiquitination[1, 2]
294LVLEDVEKKKKKSGTubiquitination[1]
413TLSNLARKEYTVGETubiquitination[1]
510NEILSGIKILKYFAWubiquitination[1, 2]
513LSGIKILKYFAWEPSubiquitination[2]
615VSTERLEKYLGGDDLubiquitination[1]
728FGTEFNEKRYQQVLEubiquitination[1, 2]
940TRNVNSLKEDEELVKubiquitination[1, 2]
947KEDEELVKGQKLIKKubiquitination[1, 2]
1184EHQQRFLKHNEVRIDubiquitination[1]
1277ERITEYTKVENEAPWubiquitination[1, 2, 3]
1288EAPWVTDKRPPPDWPubiquitination[2]
1376GLHDLREKLTIIPQDubiquitination[2]
1408YSDEEIWKALELAHLubiquitination[1]
1544IENVNSTKF******ubiquitination[1, 2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. 
Sequence Annotation
 DOMAIN 322 605 ABC transmembrane type-1 1.
 DOMAIN 637 861 ABC transporter 1.
 DOMAIN 979 1264 ABC transmembrane type-1 2.
 DOMAIN 1300 1534 ABC transporter 2.
 NP_BIND 671 678 ATP 1 (Potential).
 NP_BIND 1334 1341 ATP 2 (Potential).
 MOD_RES 283 283 Phosphoserine.
 MOD_RES 878 878 Phosphoserine.
 CARBOHYD 7 7 N-linked (GlcNAc...) (Potential).
 CARBOHYD 12 12 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1011 1011 N-linked (GlcNAc...) (Potential).  
Keyword
 ATP-binding; Complete proteome; Disease mutation; Glycoprotein; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1545 AA 
Protein Sequence
MLEKFCNSTF WNSSFLDSPE ADLPLCFEQT VLVWIPLGYL WLLAPWQLLH VYKSRTKRSS 60
TTKLYLAKQV FVGFLLILAA IELALVLTED SGQATVPAVR YTNPSLYLGT WLLVLLIQYS 120
RQWCVQKNSW FLSLFWILSI LCGTFQFQTL IRTLLQGDNS NLAYSCLFFI SYGFQILILI 180
FSAFSENNES SNNPSSIASF LSSITYSWYD SIILKGYKRP LTLEDVWEVD EEMKTKTLVS 240
KFETHMKREL QKARRALQRR QEKSSQQNSG ARLPGLNKNQ SQSQDALVLE DVEKKKKKSG 300
TKKDVPKSWL MKALFKTFYM VLLKSFLLKL VNDIFTFVSP QLLKLLISFA SDRDTYLWIG 360
YLCAILLFTA ALIQSFCLQC YFQLCFKLGV KVRTAIMASV YKKALTLSNL ARKEYTVGET 420
VNLMSVDAQK LMDVTNFMHM LWSSVLQIVL SIFFLWRELG PSVLAGVGVM VLVIPINAIL 480
STKSKTIQVK NMKNKDKRLK IMNEILSGIK ILKYFAWEPS FRDQVQNLRK KELKNLLAFS 540
QLQCVVIFVF QLTPVLVSVV TFSVYVLVDS NNILDAQKAF TSITLFNILR FPLSMLPMMI 600
SSMLQASVST ERLEKYLGGD DLDTSAIRHD CNFDKAMQFS EASFTWEHDS EATVRDVNLD 660
IMAGQLVAVI GPVGSGKSSL ISAMLGEMEN VHGHITIKGT TAYVPQQSWI QNGTIKDNIL 720
FGTEFNEKRY QQVLEACALL PDLEMLPGGD LAEIGEKGIN LSGGQKQRIS LARATYQNLD 780
IYLLDDPLSA VDAHVGKHIF NKVLGPNGLL KGKTRLLVTH SMHFLPQVDE IVVLGNGTIV 840
EKGSYSALLA KKGEFAKNLK TFLRHTGPEE EATVHDGSEE EDDDYGLISS VEEIPEDAAS 900
ITMRRENSFR RTLSRSSRSN GRHLKSLRNS LKTRNVNSLK EDEELVKGQK LIKKEFIETG 960
KVKFSIYLEY LQAIGLFSIF FIILAFVMNS VAFIGSNLWL SAWTSDSKIF NSTDYPASQR 1020
DMRVGVYGAL GLAQGIFVFI AHFWSAFGFV HASNILHKQL LNNILRAPMR FFDTTPTGRI 1080
VNRFAGDIST VDDTLPQSLR SWITCFLGII STLVMICMAT PVFTIIVIPL GIIYVSVQMF 1140
YVSTSRQLRR LDSVTRSPIY SHFSETVSGL PVIRAFEHQQ RFLKHNEVRI DTNQKCVFSW 1200
ITSNRWLAIR LELVGNLTVF FSALMMVIYR DTLSGDTVGF VLSNALNITQ TLNWLVRMTS 1260
EIETNIVAVE RITEYTKVEN EAPWVTDKRP PPDWPSKGKI QFNNYQVRYR PELDLVLRGI 1320
TCDIGSMEKI GVVGRTGAGK SSLTNCLFRI LEAAGGQIII DGVDIASIGL HDLREKLTII 1380
PQDPILFSGS LRMNLDPFNN YSDEEIWKAL ELAHLKSFVA SLQLGLSHEV TEAGGNLSIG 1440
QRQLLCLGRA LLRKSKILVL DEATAAVDLE TDNLIQTTIQ NEFAHCTVIT IAHRLHTIMD 1500
SDKVMVLDNG KIIECGSPEE LLQIPGPFYF MAKEAGIENV NSTKF 1545 
Gene Ontology
 GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0046581; C:intercellular canaliculus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; TAS:ProtInc.
 GO:0008514; F:organic anion transmembrane transporter activity; TAS:ProtInc.
 GO:0030644; P:cellular chloride ion homeostasis; IEA:Compara.
 GO:0006855; P:drug transmembrane transport; IEA:Compara.
 GO:0015732; P:prostaglandin transport; IEA:Compara.
 GO:0046685; P:response to arsenic-containing substance; IEA:Compara.
 GO:0009408; P:response to heat; IEA:Compara.
 GO:0031427; P:response to methotrexate; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0070327; P:thyroid hormone transport; IEA:Compara. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR005292; Multidrug-R_assoc.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS