CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005814
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock 70 kDa protein cognate 3 
Protein Synonyms/Alias
 78 kDa glucose-regulated protein homolog; GRP 78; Heat shock protein cognate 72 
Gene Name
 Hsc70-3 
Gene Synonyms/Alias
 Hsc3; CG4147 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
268RVMDHFIKLYKKKKGacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. 
Sequence Annotation
 MOTIF 653 656 Prevents secretion from ER (Potential).  
Keyword
 ATP-binding; Complete proteome; Endoplasmic reticulum; Nucleotide-binding; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 656 AA 
Protein Sequence
MKLCILLAVV AFVGLSLGEE KKEKDKELGT VIGIDLGTTY SCVGVYKNGR VEIIANDQGN 60
RITPSYVAFT ADGERLIGDA AKNQLTTNPE NTVFDAKRLI GREWSDTNVQ HDIKFFPFKV 120
VEKNSKPHIS VDTSQGAKVF APEEISAMVL GKMKETAEAY LGKKVTHAVV TVPAYFNDAQ 180
RQATKDAGVI AGLQVMRIIN EPTAAAIAYG LDKKEGEKNV LVFDLGGGTF DVSLLTIDNG 240
VFEVVATNGD THLGGEDFDQ RVMDHFIKLY KKKKGKDIRK DNRAVQKLRR EVEKAKRALS 300
GSHQVRIEIE SFFEGDDFSE TLTRAKFEEL NLDLFRSTLK PVQKVLEDAD MNKKDVHEIV 360
LVGGSTRIPK VQQLVKDFFG GKEPSRGINP DEAVAYGAAV QAGVLSGEQD TDAIVLLDVN 420
PLTMGIETVG GVMTKLIPRN TVIPTKKSQV FSTASDNQHT VTIQVYEGER PMTKDNHLLG 480
KFDLTGIPPA PRGIPQIEVS FEIDANGILQ VSAEDKGTGN KEKIVITNDQ NRLTPEDIDR 540
MIRDAEKFAD EDKKLKERVE SRNELESYAY SLKNQIGDKD KLGAKLSDDE KNKLESAIDE 600
SIKWLEQNPD ADPEEYKKQK KDLEAIVQPV IAKLYQGAGG APPPEGGDDA DLKDEL 656 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:FlyBase.
 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0005615; C:extracellular space; IDA:FlyBase.
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051298; P:centrosome duplication; IMP:FlyBase.
 GO:0016246; P:RNA interference; IMP:FlyBase.
 GO:0030431; P:sleep; TAS:FlyBase. 
Interpro
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS00014; ER_TARGET
 PS00297; HSP70_1
 PS00329; HSP70_2
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.