UniProt Accession

 RAB6A_HUMAN; P20340; A8K133; B7Z772; F5H668; Q1W5D8; Q5U0A8; Q9UBE4 

Genbank Protein ID

 M28212; AF130986; AF119836; AF198616; AF130122; DQ437503; AK057157; AK289748; AK290132; AK301534; AF498939; AF498941; BT019698; AP002770; AP002993; BC003617; BC068486; BC096818 

Genbank Nucleotide ID

 AAA60246.1; AAD25535.1; AAF23593.1; AAF73841.1; AAD27707.1; ABD93919.1; BAB71371.1; BAF82437.1; BAF82821.1; BAH13508.1; AAM21087.1; AAM21089.1; AAV38504.1; AAH03617.1; AAH68486.1; AAH96818.1 

Protein Name

 Ras-related protein Rab-6A 

Protein Synonyms/Alias

 Rab-6 

Gene Name

 RAB6A 

Gene Synonyms/Alias

 RAB6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
26	LGEQSVGKTSLITRF	ubiquitination	[1]
127	IIMLVGNKTDLADKR	ubiquitination	[1]
164	AKAGYNVKQLFRRVA	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. 

Sequence Annotation

 NP_BIND 20 28 GTP.
 NP_BIND 68 72 GTP.
 NP_BIND 126 129 GTP.
 NP_BIND 156 158 GTP.
 MOTIF 42 50 Effector region (By similarity).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 82 82 O-AMP-tyrosine; by Legionella DrrA.
 MOD_RES 180 180 Phosphothreonine (By similarity).
 MOD_RES 208 208 Cysteine methyl ester (By similarity).
 LIPID 206 206 S-geranylgeranyl cysteine (By
 LIPID 208 208 S-geranylgeranyl cysteine (By  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 208 AA 

Protein Sequence

Gene Ontology

 GO:0031410; C:cytoplasmic vesicle; IDA:BHF-UCL.
 GO:0005829; C:cytosol; IDA:BHF-UCL.
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IDA:BHF-UCL.
 GO:0005802; C:trans-Golgi network; IDA:BHF-UCL.
 GO:0005525; F:GTP binding; IDA:UniProtKB.
 GO:0003924; F:GTPase activity; IDA:UniProtKB.
 GO:0072385; P:minus-end-directed organelle transport along microtubule; TAS:BHF-UCL.
 GO:0018125; P:peptidyl-cysteine methylation; IDA:MGI.
 GO:0000042; P:protein targeting to Golgi; IDA:UniProtKB.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; TAS:BHF-UCL.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.