UniProt Accession

 FADS1_MOUSE; Q920L1; Q3U494; Q8BZX7; Q8R0G8; Q8VC07 

Genbank Protein ID

 AB072976; AK033308; AK083959; AK154367; BC022139; BC026831; BC026848; BC063053 

Genbank Nucleotide ID

 BAB69894.1; BAC28228.1; BAC39079.1; BAE32539.1; AAH22139.1; AAH26831.1; AAH26848.1; AAH63053.1 

Protein Name

 Fatty acid desaturase 1 

Protein Synonyms/Alias

 Delta(5) fatty acid desaturase; D5D; Delta(5) desaturase; Delta-5 desaturase 

Gene Name

 Fads1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
44	RWLVIDRKVYNISDF	ubiquitination	[1]
81	FVAFHINKGLVRKYM	ubiquitination	[1]
86	INKGLVRKYMNSLLI	ubiquitination	[1]
107	QPSFEPTKNKALTDE	ubiquitination	[1]
109	SFEPTKNKALTDEFR	ubiquitination	[1]
231	AKPNCFRKDPDINMH	ubiquitination	[1]
246	PLFFALGKVLPVELG	ubiquitination	[1]
401	MPRHNYHKVAPLVQS	ubiquitination	[1]
412	LVQSLCAKYGIKYES	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3) respectively (By similarity). 

Sequence Annotation

 DOMAIN 19 97 Cytochrome b5 heme-binding.
 MOTIF 182 186 Histidine box-1.
 MOTIF 219 223 Histidine box-2.
 MOTIF 385 389 Histidine box-3.  

Keyword

 Complete proteome; Electron transport; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Membrane; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 447 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0016717; F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0019369; P:arachidonic acid metabolic process; IEA:Compara.
 GO:0009267; P:cellular response to starvation; IEA:Compara.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0032868; P:response to insulin stimulus; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0009744; P:response to sucrose stimulus; IEA:Compara.
 GO:0033189; P:response to vitamin A; IEA:Compara.
 GO:0006636; P:unsaturated fatty acid biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001199; Cyt_B5-like_heme/steroid-bd.
 IPR012171; Fatty_acid/sphinglp_desaturase.
 IPR005804; Fatty_acid_desaturase-1. 

Pfam

 PF00173; Cyt-b5
 PF00487; FA_desaturase 

SMART

  

PROSITE

 PS00191; CYTOCHROME_B5_1
 PS50255; CYTOCHROME_B5_2 

PRINTS

 PR00363; CYTOCHROMEB5.