UniProt Accession

 AMGO2_HUMAN; Q86SJ2; Q4VBP6; Q7Z4A0; Q96CN8 

Genbank Protein ID

 AY237005; AB079074; AB080610; AY454159; AL833007; BC014103; BC047595; BC095477 

Genbank Nucleotide ID

 AAO48946.1; BAC81188.1; BAC81189.1; AAR83271.1; CAH56293.1; AAH14103.2; AAH47595.1; AAH95477.1 

Protein Name

 Amphoterin-induced protein 2 

Protein Synonyms/Alias

 AMIGO-2; Alivin-1; Differentially expressed in gastric adenocarcinomas; DEGA 

Gene Name

 AMIGO2 

Gene Synonyms/Alias

 ALI1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
432	KCKTKRQKNMLHQSN	ubiquitination	[1]
473	VVFLEPLKDTAAGQN	ubiquitination	[1]
482	TAAGQNGKVRLFPSE	ubiquitination	[1]
498	VIAEGILKSTRGKSD	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas. 

Sequence Annotation

 DOMAIN 40 68 LRRNT.
 REPEAT 69 90 LRR 1.
 REPEAT 94 115 LRR 2.
 REPEAT 118 139 LRR 3.
 REPEAT 142 163 LRR 4.
 REPEAT 166 187 LRR 5.
 REPEAT 193 214 LRR 6.
 DOMAIN 228 284 LRRCT.
 DOMAIN 289 379 Ig-like C2-type.
 CARBOHYD 58 58 N-linked (GlcNAc...) (Potential).
 CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
 CARBOHYD 281 281 N-linked (GlcNAc...) (Potential).
 CARBOHYD 288 288 N-linked (GlcNAc...) (Potential).
 CARBOHYD 345 345 N-linked (GlcNAc...) (Potential).
 CARBOHYD 373 373 N-linked (GlcNAc...) (Potential).
 CARBOHYD 381 381 N-linked (GlcNAc...) (Potential).
 CARBOHYD 384 384 N-linked (GlcNAc...) (Potential).
 DISULFID 41 47 By similarity.
 DISULFID 45 54 By similarity.
 DISULFID 232 260 By similarity.
 DISULFID 234 282 By similarity.
 DISULFID 310 363 By similarity.  

Keyword

 Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat; Membrane; Nucleus; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 522 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0007157; P:heterophilic cell-cell adhesion; ISS:UniProtKB.
 GO:0007156; P:homophilic cell adhesion; ISS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0043069; P:negative regulation of programmed cell death; ISS:UniProtKB. 

Interpro

 IPR000483; Cys-rich_flank_reg_C.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N. 

Pfam

 PF00560; LRR_1 

SMART

 SM00409; IG
 SM00369; LRR_TYP
 SM00082; LRRCT
 SM00013; LRRNT 

PROSITE

 PS50835; IG_LIKE
 PS51450; LRR 

PRINTS