| Tag | Content |
|---|
| CPLM ID | CPLM-000706 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Synaptojanin-1 |
Protein Synonyms/Alias | Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1 |
Gene Name | SYNJ1 |
Gene Synonyms/Alias | KIAA0910 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 5 | ***MAFSKGFRIYHK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis. |
Sequence Annotation | DOMAIN 119 442 SAC.
DOMAIN 902 971 RRM.
REPEAT 1396 1398 1.
REPEAT 1406 1408 2.
REPEAT 1417 1419 3.
REGION 500 899 Catalytic (Potential).
REGION 1396 1419 3 X 3 AA repeats of N-P-F.
MOD_RES 784 784 Phosphotyrosine (By similarity).
MOD_RES 786 786 Phosphotyrosine (By similarity).
MOD_RES 830 830 Phosphoserine.
MOD_RES 1048 1048 Phosphothreonine (By similarity).
MOD_RES 1053 1053 Phosphoserine (By similarity).
MOD_RES 1084 1084 Phosphoserine (By similarity).
MOD_RES 1150 1150 Phosphoserine (By similarity).
MOD_RES 1220 1220 Phosphothreonine.
MOD_RES 1318 1318 Phosphoserine.
MOD_RES 1345 1345 Phosphoserine (By similarity).
MOD_RES 1349 1349 Phosphothreonine (By similarity).
MOD_RES 1551 1551 Phosphoserine.
MOD_RES 1565 1565 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Endocytosis; Hydrolase; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1573 AA |
Protein Sequence | MAFSKGFRIY HKLDPPPFSL IVETRHKEEC LMFESGAVAV LSSAEKEAIK GTYSKVLDAY 60
GLLGVLRLNL GDTMLHYLVL VTGCMSVGKI QESEVFRVTS TEFISLRIDS SDEDRISEVR 120
KVLNSGNFYF AWSASGISLD LSLNAHRSMQ EQTTDNRFFW NQSLHLHLKH YGVNCDDWLL 180
RLMCGGVEIR TIYAAHKQAK ACLISRLSCE RAGTRFNVRG TNDDGHVANF VETEQVVYLD 240
DSVSSFIQIR GSVPLFWEQP GLQVGSHRVR MSRGFEANAP AFDRHFRTLK NLYGKQIIVN 300
LLGSKEGEHM LSKAFQSHLK ASEHAADIQM VNFDYHQMVK GGKAEKLHSV LKPQVQKFLD 360
YGFFYFNGSE VQRCQSGTVR TNCLDCLDRT NSVQAFLGLE MLAKQLEALG LAEKPQLVTR 420
FQEVFRSMWS VNGDSISKIY AGTGALEGKA KLKDGARSVT RTIQNNFFDS SKQEAIDVLL 480
LGNTLNSDLA DKARALLTTG SLRVSEQTLQ SASSKVLKSM CENFYKYSKP KKIRVCVGTW 540
NVNGGKQFRS IAFKNQTLTD WLLDAPKLAG IQEFQDKRSK PTDIFAIGFE EMVELNAGNI 600
VSASTTNQKL WAVELQKTIS RDNKYVLLAS EQLVGVCLFV FIRPQHAPFI RDVAVDTVKT 660
GMGGATGNKG AVAIRMLFHT TSLCFVCSHF AAGQSQVKER NEDFIEIARK LSFPMGRMLF 720
SHDYVFWCGD FNYRIDLPNE EVKELIRQQN WDSLIAGDQL INQKNAGQVF RGFLEGKVTF 780
APTYKYDLFS DDYDTSEKCR TPAWTDRVLW RRRKWPFDRS AEDLDLLNAS FQDESKILYT 840
WTPGTLLHYG RAELKTSDHR PVVALIDIDI FEVEAEERQN IYKEVIAVQG PPDGTVLVSI 900
KSSLPENNFF DDALIDELLQ QFASFGEVIL IRFVEDKMWV TFLEGSSALN VLSLNGKELL 960
NRTITIALKS PDWIKNLEEE MSLEKISIAL PSSTSSTLLG EDAEVAADFD MEGDVDDYSA 1020
EVEELLPQHL QPSSSSGLGT SPSSSPRTSP CQSPTISEGP VPSLPIRPSR APSRTPGPPS 1080
AQSSPIDAQP ATPLPQKDPA QPLEPKRPPP PRPVAPPTRP APPQRPPPPS GARSPAPTRK 1140
EFGGIGAPPS PGVARREMEA PKSPGTTRKD NIGRSQPSPQ AGLAGPGPAG YSTARPTIPP 1200
RAGVISAPQS HARASAGRLT PESQSKTSET SKGSTFLPEP LKPQAAFPPQ SSLPPPAQRL 1260
QEPLVPVAAP MPQSGPQPNL ETPPQPPPRS RSSHSLPSEA SSQPQVKTNG ISDGKRESPL 1320
KIDPFEDLSF NLLAVSKAQL SVQTSPVPTP DPKRLIQLPS ATQSNVLSSV SCMPTMPPIP 1380
ARSQSQENMR SSPNPFITGL TRTNPFSDRT AAPGNPFRAK SEESEATSWF SKEEPVTISP 1440
FPSLQPLGHN KSRASSSLDG FKDSFDLQGQ STLKISNPKG WVTFEEEEDF GVKGKSKSAC 1500
SDLLGNQPSS FSGSNLTLND DWNKGTNVSF CVLPSRRPPP PPVPLLPPGT SPPVDPFTTL 1560
ASKASPTLDF TER 1573 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; TAS:ProtInc. GO:0000166; F:nucleotide binding; IEA:InterPro. GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome. GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome. GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro. GO:0048488; P:synaptic vesicle endocytosis; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |