CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013705
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vacuolar protein sorting-associated protein 41 homolog 
Protein Synonyms/Alias
 VAM2 homolog; mVAM2 
Gene Name
 Vps41 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
761LLREGCKKILVADSLubiquitination[1]
772ADSLSLLKKMHRTQMubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Required for vacuolar assembly and vacuolar traffic (By similarity). 
Sequence Annotation
 REPEAT 567 711 CHCR.
 ZN_FING 790 838 RING-type; atypical.  
Keyword
 Complete proteome; Metal-binding; Protein transport; Reference proteome; Transport; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 853 AA 
Protein Sequence
MAEAEEQETE SLEESTDESE EESEEEPKLK YERLSNGVTE ILQKDAASCM TVHDKFLALG 60
THYGKVYLLD VQGNITQKFD VSPVKINQIS LDDSGEHMGV CSEDGKLQVF GLYSGEEFHE 120
TFDCPIKIIA VHPQFVRSSC KQFVTGGKKL LLFERTWMNR WKSSVLHEGE GNIRSVKWRG 180
HLIAWANNMG VKVFDITSKQ RISNVPRDDI SLRPDMYPCS LCWKDNVTLI IGWGTSIKIC 240
SVKERHASEM RDLPSRYVEI VSQFETEFYI SGLAPLCDQL VVLSYVKEVS EKTEREYCAR 300
PRLDIIQPLP ETCEEISSDA LTVRGFQENE CRDYHLEYSE GESLFYVVSP RDVVVAKERD 360
QDDHIDWLLE KKKYEEALMA AEISQRNIKR HKILDIGLAY VNHLVERGEY DMAARKCQKI 420
LGKNASLWEY EVYKFKEIGQ LKAISPYLPR GDPVLKPLIY EMILHEFLES DYEGFATLIR 480
EWPGDLYNNS VIVQAVRDHL KKDSQNKTLL KTLAELYTYD KNYGNALEIY LTLRHKDVFQ 540
LIHKHNLFSS IKDKIVLLMD FDSEKAVDML LDNEDKISIK KVVEELEDRP ELQHVYLHKL 600
FKRDHHKGQR YHEKQISLYA EYDRPNLLPF LRDSTHCPLE KALEICQQRN FVEETVYLLS 660
RMGNSRSALK MIMEELHDVD KAIEFAKEQD DGELWEDLIL YSIDKPPFIT GLLNNIGTHV 720
DPILLIHRIK EGMEIPNLRD SLVKILQDYN LQILLREGCK KILVADSLSL LKKMHRTQMK 780
GVLVDEENIC ESCLSPILPT DAAKPFSVVV FHCRHMFHKE CLPMPSMNAP AQYCNICSAK 840
NRGPGSAILE MKK 853 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005769; C:early endosome; IDA:MGI.
 GO:0005798; C:Golgi-associated vesicle; IEA:Compara.
 GO:0030897; C:HOPS complex; IEA:Compara.
 GO:0005770; C:late endosome; IDA:MGI.
 GO:0005874; C:microtubule; IDA:MGI.
 GO:0008017; F:microtubule binding; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0048193; P:Golgi vesicle transport; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR000547; Clathrin_H-chain/VPS_repeat.
 IPR011990; TPR-like_helical.
 IPR016902; VPS41.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR017986; WD40_repeat_dom.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00637; Clathrin 
SMART
 SM00299; CLH
 SM00184; RING 
PROSITE
 PS50236; CHCR
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS