CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028039
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GH12714p 
Protein Synonyms/Alias
 Protein phosphatase 5; Protein phosphatase D3, isoform A; Protein phosphatase D3, isoform B 
Gene Name
 PpD3 
Gene Synonyms/Alias
 PPP5; CG8402; Dmel_CG8402 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
156NDKDAKLKFTECNKIacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
 ACT_SITE 326 326 Proton donor (By similarity).
 METAL 264 264 Iron (By similarity).
 METAL 266 266 Iron (By similarity).
 METAL 293 293 Iron (By similarity).  
Keyword
 Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 520 AA 
Protein Sequence
MSSSELEVQK AADCQQEAKV PASVEITGSK QPEEDTNART KAELDFAAAE QYKNQGNEML 60
KTKEFSKAID MYTKAIELHP NSAIYYANRS LAHLRQESFG FALQDGVSAV KADPAYLKGY 120
YRRAAAHMSL GKFKQALCDF EFVAKCRPND KDAKLKFTEC NKIVKMRAFE RAIAVDKPEK 180
TLSEMYSDME NITIEDDYKG PQLEDGKVTL KFMKELMEHY KAQKRLHRKF AYKILCEIDT 240
YMRAQPSLVD ITVPDEEKFT ICGDIHGQFY DLMNIFEING LPSEKNPYLF NGDFVDRGSF 300
SVECIFTLFG FKLLYPNHFF LARGNHESIN MNQMYGFTGE VTAKYTSAMA DIFTQVFNWL 360
PLCHCINQKI LVMHGGLFST EDVTLDHIRR IERNCQPPEE GLMCELLWSD PQQWMGLGQS 420
KRGVGIQFGP DVTEKFCKDN NLDYIIRSHE VKDMGYEVAH NGKCITVFSA PNYCDTMGNM 480
GAFITITGNN LKPNYKSFEA VPHPDVKPMA YANSLMNWLA 520 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:FlyBase.
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004722; F:protein serine/threonine phosphatase activity; ISS:FlyBase.
 GO:0000278; P:mitotic cell cycle; IMP:FlyBase.
 GO:0006470; P:protein dephosphorylation; ISS:FlyBase. 
Interpro
 IPR004843; Metallo_PEstase_dom.
 IPR013235; PPP_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase.
 IPR011236; Ser/Thr_PPase_5.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00149; Metallophos
 PF08321; PPP5
 PF00515; TPR_1 
SMART
 SM00156; PP2Ac
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS
 PR00114; STPHPHTASE.