CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018731
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein SMG7 
Protein Synonyms/Alias
 EST1-like protein C; SMG-7 homolog; hSMG-7 
Gene Name
 SMG7 
Gene Synonyms/Alias
 C1orf16; EST1C; KIAA0250 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
66DLWNHAFKNQITTLQubiquitination[1]
464QRLISIGKWIADNQPubiquitination[2]
771LGKIMPVKQPYYLQTubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. 
Sequence Annotation
 REPEAT 152 185 TPR 1.
 REPEAT 187 219 TPR 2.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 520 520 Phosphoserine.
 MOD_RES 781 781 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nonsense-mediated mRNA decay; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1137 AA 
Protein Sequence
MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY ALDKKVEQDL 60
WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG FYTQLLQELC TVFNVDLPCR 120
VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ 180
LVPSNGQPYN QLAILASSKG DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV 240
KTKWGVSDFI KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI 300
NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE SQEESYNAYP 360
LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF HPHEEDLSSI SATPLPEEFE 420
LQGFLALRPS FRNLDFSKGH QGITGDKEGQ QRRIRQQRLI SIGKWIADNQ PRLIQCENEV 480
GKLLFITEIP ELILEDPSEA KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG 540
EKPVVTFKEN IKTREVNRDQ GRSFPPKEVK SQTELRKTPV SEARKTPVTQ TPTQASNSQF 600
IPIHHPGAFP PLPSRPGFPP PTYVIPPPVA FSMGSGYTFP AGVSVPGTFL QPTAHSPAGN 660
QVQAGKQSHI PYSQQRPSGP GPMNQGPQQS QPPSQQPLTS LPAQPTAQST SQLQVQALTQ 720
QQQSPTKAVP ALGKSPPHHS GFQQYQQADA SKQLWNPPQV QGPLGKIMPV KQPYYLQTQD 780
PIKLFEPSLQ PPVMQQQPLE KKMKPFPMEP YNHNPSEVKV PEFYWDSSYS MADNRSVMAQ 840
QANIDRRGKR SPGVFRPEQD PVPRMPFEDP KSSPLLPPDL LKSLAALEEE EELIFSNPPD 900
LYPALLGPLA SLPGRSLFKS LLEKPSELMS HSSSFLSLTG FSLNQERYPN NSMFNEVYGK 960
NLTSSSKAEL SPSMAPQETS LYSLFEGTPW SPSLPASSDH STPASQSPHS SNPSSLPSSP 1020
PTHNHNSVPF SNFGPIGTPD NRDRRTADRW KTDKPAMGGF GIDYLSATSS SESSWHQAST 1080
PSGTWTGHGP SMEDSSAVLM ESLKKQQHGV QQLGPKRQSE EEGSSSICVA HRGPRPLPSC 1140
SLPASTFRVK FKAARTCAHQ AQKKTRRRPF WKRRKKGK 1178 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HGNC.
 GO:0051721; F:protein phosphatase 2A binding; IDA:HGNC.
 GO:0010467; P:gene expression; TAS:Reactome.
 GO:0006406; P:mRNA export from nucleus; TAS:HGNC.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:HGNC.
 GO:0035303; P:regulation of dephosphorylation; TAS:HGNC. 
Interpro
 IPR018834; DNA/RNA-bd_Est1-type.
 IPR019458; EST1.
 IPR011990; TPR-like_helical. 
Pfam
 PF10374; EST1
 PF10373; EST1_DNA_bind 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS