UniProt Accession

 A2AAW9_MOUSE; A2AAW9 

Genbank Protein ID

 AL646049; AL646092 

Genbank Nucleotide ID

  

Protein Name

 Eukaryotic translation initiation factor 2 subunit 3, X-linked 

Protein Synonyms/Alias

  

Gene Name

 Eif2s3x 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
27	LATLDVTKLTPLSHE	acetylation	[1]
27	LATLDVTKLTPLSHE	ubiquitination	[2]
59	HGKSTVVKAISGVHT	acetylation	[1]
90	YANAKIYKLDDPSCP	acetylation	[1]
90	YANAKIYKLDDPSCP	ubiquitination	[2]
121	PTDIPGTKGNFKLVR	ubiquitination	[2]
125	PGTKGNFKLVRHVSF	acetylation	[1]
183	AIEIMKLKHILILQN	acetylation	[1]
191	HILILQNKIDLVKES	acetylation	[1]
191	HILILQNKIDLVKES	ubiquitination	[2]
196	QNKIDLVKESQAKEQ	ubiquitination	[2]
266	IRSFDVNKPGCEVDD	acetylation	[1]
266	IRSFDVNKPGCEVDD	ubiquitination	[2]
275	GCEVDDLKGGVAGGS	ubiquitination	[2]
285	VAGGSILKGVLKVGQ	acetylation	[1]
285	VAGGSILKGVLKVGQ	ubiquitination	[2]
289	SILKGVLKVGQEIEV	ubiquitination	[2]
312	SEGKLMCKPIFSKIV	acetylation	[1, 3]
312	SEGKLMCKPIFSKIV	succinylation	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 344 AA 

Protein Sequence

Gene Ontology

 GO:0005525; F:GTP binding; IEA:InterPro.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 

Interpro

 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR009000; Transl_elong_init/rib_B-barrel. 

Pfam

 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2 

SMART

  

PROSITE

  

PRINTS

 PR00315; ELONGATNFCT.