UniProt Accession

 H31_SCHPO; P09988 

Genbank Protein ID

 X05222; X05223; AB004538; CU329670; CU329671 

Genbank Nucleotide ID

 CAA28851.1; CAA28852.1; BAA21441.1; CAB75772.1; CAA17819.1 

Protein Name

 Histone H3.1/H3.2 

Protein Synonyms/Alias

  

Gene Name

 hht1; hht2 

Gene Synonyms/Alias

 SPAC1834.04; pi060; SPBC8D2.04 

Created Date

 July 27, 2013 

Organism

 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 

NCBI Taxa ID

 284812 

Lysine Modification

Position	Peptide	Type	References
57	REIRRYQKSTELLIR	acetylation	[1]

Reference

 [1] Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombe.
 Xhemalce B, Miller KM, Driscoll R, Masumoto H, Jackson SP, Kouzarides T, Verreault A, Arcangioli B.
 J Biol Chem. 2007 May 18;282(20):15040-7. [PMID: 17369611] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 5 5 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 5 5 N6,N6-dimethyllysine; alternate (By
 MOD_RES 5 5 N6-methyllysine; alternate (By
 MOD_RES 10 10 N6-acetyllysine; alternate (By
 MOD_RES 10 10 N6-methyllysine; alternate.
 MOD_RES 11 11 Phosphoserine (By similarity).
 MOD_RES 15 15 N6,N6-dimethyllysine; alternate (By
 MOD_RES 15 15 N6-acetyllysine; alternate (By
 MOD_RES 19 19 N6-acetyllysine; alternate (By
 MOD_RES 19 19 N6-methyllysine; alternate (By
 MOD_RES 24 24 N6-acetyllysine; alternate (By
 MOD_RES 24 24 N6-methyllysine; alternate (By
 MOD_RES 28 28 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 28 28 N6,N6-dimethyllysine; alternate (By
 MOD_RES 28 28 N6-acetyllysine; alternate (By
 MOD_RES 28 28 N6-methyllysine; alternate (By
 MOD_RES 37 37 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 37 37 N6,N6-dimethyllysine; alternate.
 MOD_RES 37 37 N6-acetyllysine; alternate (By
 MOD_RES 37 37 N6-methyllysine; alternate (By
 MOD_RES 57 57 N6-acetyllysine (By similarity).
 MOD_RES 65 65 N6-acetyllysine (By similarity).
 MOD_RES 80 80 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 80 80 N6,N6-dimethyllysine; alternate (By
 MOD_RES 80 80 N6-methyllysine; alternate (By  

Keyword

 3D-structure; Acetylation; Chromosome; Complete proteome; DNA damage; DNA repair; DNA-binding; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 136 AA 

Protein Sequence

Gene Ontology

 GO:0031934; C:mating-type region heterochromatin; IDA:PomBase.
 GO:0031618; C:nuclear centromeric heterochromatin; IDA:PomBase.
 GO:0000788; C:nuclear nucleosome; NAS:PomBase.
 GO:0031933; C:telomeric heterochromatin; IDA:PomBase.
 GO:0003677; F:DNA binding; NAS:PomBase.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; NAS:PomBase.
 GO:0006974; P:response to DNA damage stimulus; IMP:PomBase. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000164; Histone_H3. 

Pfam

 PF00125; Histone 

SMART

 SM00428; H3 

PROSITE

 PS00322; HISTONE_H3_1
 PS00959; HISTONE_H3_2 

PRINTS

 PR00622; HISTONEH3.