CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002399
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HTH-type transcriptional regulator EbgR 
Protein Synonyms/Alias
 Ebg operon repressor 
Gene Name
 ebgR 
Gene Synonyms/Alias
 b3075; JW3046 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
31DDPTLNVKEETKHRIacetylation[1]
44RILEIAEKLEYKTSSacetylation[1]
163IDLARISKEIIDFYIacetylation[1]
188GGEDEPGKADIREVAacetylation[1]
226SSGYELAKQMLAREDacetylation[1]
319LLVFVPSKLKLRGTTacetylation[1]
321VFVPSKLKLRGTTR*acetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Repressor for beta galactosidase alpha and beta subunits (ebgA and ebgC). Binds lactose as an inducer. 
Sequence Annotation
 DOMAIN 1 57 HTH lacI-type.
 DNA_BIND 4 23 H-T-H motif (By similarity).  
Keyword
 Complete proteome; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 327 AA 
Protein Sequence
MATLKDIAIE AGVSLATVSR VLNDDPTLNV KEETKHRILE IAEKLEYKTS SARKLQTGAV 60
NQHHILAIYS YQQELEINDP YYLAIRHGIE TQCEKLGIEL TNCYEHSGLP DIKNVTGILI 120
VGKPTPALRA AASALTDNIC FIDFHEPGSG YDAVDIDLAR ISKEIIDFYI NQGVNRIGFI 180
GGEDEPGKAD IREVAFAEYG RLKQVVREED IWRGGFSSSS GYELAKQMLA REDYPKALFV 240
ASDSIAIGVL RAIHERGLNI PQDISLISVN DIPTARFTFP PLSTVRIHSE MMGSQGVNLV 300
YEKARDGRAL PLLVFVPSKL KLRGTTR 327 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR010982; Lambda_DNA-bd_dom.
 IPR000843; Tscrpt_reg_HTH_LacI. 
Pfam
 PF00356; LacI 
SMART
 SM00354; HTH_LACI 
PROSITE
 PS00356; HTH_LACI_1
 PS50932; HTH_LACI_2 
PRINTS
 PR00036; HTHLACI.