CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038832
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cytochrome P450 2D3 
Protein Synonyms/Alias
  
Gene Name
 Cyp2d3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
436DAQGNFVKHEAFMPFacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
MELLAGTGLW PMAIFTVIFI LLVDLMHRRQ RWTSRYPPGP VPWPVLGNLL QVDLCNMPYS 60
MYKLQNRYGD VFSLQMGWKP VVVINGLKAV QELLVTCGED TADRPEMPIF QHIGYGHKAK 120
GKRLCVVLAP YGPEWREQRR FSVSTLRNFG VGKKSLEQWV TDEASHLCDA LTAEAGRPLD 180
PYTLLNKAVC NVIASLIYAR RFDYGDPDFI KVLKILKESM GEQTGLFPEV LNMFPVLLRI 240
PGLADKVFPG QKTFLTMVDN LVTEHKKTWD PDQPPRDLTD AFLAEIEKAK GNPESSFNDA 300
NLRLVVNDLF GAGMVTTSIT LTWALLLMIL HPDVQCRVQQ EIDEVIGQVR HPEMADQAHM 360
PFTNAVIHEV QRFADIVPMN LPHKTSRDIE VQGFLIPKGT TLIPNLSSVL KDETVWEKPL 420
RFHPEHFLDA QGNFVKHEAF MPFSAGRRAC LGEPLARMEL FLFFTCLLQR FSFSVPTGQP 480
RPSDYGVFAF LLSPSPYQLC AFKR 504 
Gene Ontology
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008069; Cyt_P450_E_grp-I_CYP2D-like. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR01686; EP450ICYP2D.
 PR00385; P450.