CPLM-017316

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-017316

UniProt Accession

PGAM4_HUMAN; Q8N0Y7; Q5JPN2; Q8NI24; Q8NI25; Q8NI26

Genbank Protein ID

AF465731; AF465732; AF465733; AF465734; AF465735; AF465736; AF465737; AF465738; AF465739; AF465740; AF465741; AF465742; AF465743; AF465744; AF465745; DQ120647; AL772330

Genbank Nucleotide ID

AAM27282.1; AAM27283.1; AAM27284.1; AAM27285.1; AAM27286.1; AAM27287.1; AAM27288.1; AAM27289.1; AAM27290.1; AAM27291.1; AAM27292.1; AAM27293.1; AAM27294.1; AAM27295.1; AAM27296.1; ABB92432.1; CAI42111.1

Protein Name

Probable phosphoglycerate mutase 4

Protein Synonyms/Alias

Gene Name

PGAM4

Gene Synonyms/Alias

PGAM3

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
106	NKAETAAKHGEAQVK	ubiquitination	[1]
113	KHGEAQVKIWRRSYD	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Sequence Annotation

ACT_SITE 11 11 Tele-phosphohistidine intermediate (By
ACT_SITE 186 186 By similarity.
MOD_RES 14 14 Phosphoserine (By similarity).
MOD_RES 26 26 Phosphotyrosine (By similarity).
MOD_RES 31 31 Phosphoserine (By similarity).
MOD_RES 118 118 Phosphoserine (By similarity).
MOD_RES 251 251 N6-acetyllysine (By similarity).
MOD_RES 253 253 N6-acetyllysine (By similarity).

Keyword

Acetylation; Complete proteome; Glycolysis; Hydrolase; Isomerase; Phosphoprotein; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

254 AA

Protein Sequence

MAAYKLVLIR HGESTWNLEN RFSCWYDADL SPAGHEEAKR GGQALRDAGY EFDICLTSVQ 60
KRVIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEA QVKIWRRSYD 120
VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSYESPKDTI ARALPFWNEE IVPQIKEGKR 180
VLIAAHGNSL QGIAKHVEGL SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVC 240
KAIEAVAAQG KAKK 254

Gene Ontology

GO:0004083; F:bisphosphoglycerate 2-phosphatase activity; IEA:EC.
GO:0004082; F:bisphosphoglycerate mutase activity; IEA:EC.
GO:0004619; F:phosphoglycerate mutase activity; NAS:UniProtKB.
GO:0006096; P:glycolysis; NAS:UniProtKB.

Interpro

IPR013078; His_Pase_superF_clade-1.
IPR001345; PG/BPGM_mutase_AS.
IPR005952; Phosphogly_mut1.

Pfam

PF00300; His_Phos_1

SMART

SM00855; PGAM

PROSITE

PS00175; PG_MUTASE

PRINTS